73例万古霉素血药浓度监测分析

Evaluation of the therapeutic drug monitoring work of vancomycin in 73 cases

目的：分析我院万古霉素血药浓度监测及临床疗效情况，促进临床个体化用药。方法对用万古霉素并监测血药浓度的73例患者的一般资料、原患疾病、病原学检测结果、抽血时间、万古霉素血药浓度、疗效、肾损害等临床资料进行统计分析。结果我院住院患者万古霉素血药浓度监测率为23．10％，万古霉素治疗有效率为67．61％，万古霉素血药谷浓度在10～20 mg· L－1的患者占40．91％，治疗后肾功能异常发生率为12．33％。结论我院万古霉素血药谷浓度总体偏低，可结合临床实际适当调整万古霉素用量。

Objective To evaluate the therapeutic drug monitoring work and the clinical effect of vancomycin in our hospital and to improve individualized medication. Methods The clinical information of 73 patients who used vancomycin were analyzed and their blood concentrations were monitored in our hospital.The contents included the patients′basic information, their primary diseases, the bacteriological culture informa-tion, the time of examination, the blood concentration of vancomycin, the therapeutic effect and the renal function damage.Results The therapeu-tic drug monitoring rate was 23.10%and the effective therapies accounted for 67.61%.The blood trough concentration during 10 -20 mg· L-1 accounted for 40.91%.The occurrence of renal dysfunction after therapy was 12.33%.Conclusion The prevalence of vancomycin therapeutic drug monitoring is relatively low in our hospital.The dosage of vancomycin should be adjusted according to clinical reality.