肿瘤分子靶向治疗药物的研究与应用进展

Research and application progress on the molecular targeted drugs for cancer

当前肿瘤分子靶向药物家族不断发展壮大。按作用靶点,可将分子靶向药物分为细胞信号转导抑制剂、抗血管生成剂、凋亡激动剂和细胞周期抑制剂等。按照药物分子大小,可分为大分子和小分子化合物。依据作用靶点的多少,又可分为单靶点和多靶点药物。本文旨在对当前已获FDA批准的、主要的分子靶向治疗药物加以分析和总结。

The tumor molecular targeted drug family keeps developing and growing nowadays.Depending on specific target types,molecular targeted agents can be classified as cellular signal transduction inhibitors,angio-genesis inhibitors, apoptosis inducers and cell cycle inhibitors.The main categories of targeted therapy include large molecular compounds and small molecular compounds.Based on the number of targets, it can also be divided into single targeted drugs and multiple targeted drugs.This re-view aimed to analyze and summarize main molecular targeted drugs approved by FDA currently.