细菌性肺炎患者IL-6及IL-8及C反应蛋白的测定及其意义

IL-6,IL-8 and C-reactive protein and their significance in bacterial pneumonia

目的探讨白细胞介素6(IL-6)、白细胞介素8(IL-8)和C反应蛋白(CRP)在细菌性肺炎患者中的水平及其临床意义。方法以120例细菌性肺炎患者为试验组,以80例健康人作为对照组;分别抽取对照组及试验组治疗前后的空腹静脉血进行IL-6、IL-8和CRP的检测。结果细菌性肺炎患者中的IL-6及IL-8及CRP均明显高于对照组,差异具有统计学意义(P<0.001)。同时与治疗前相比,细菌性肺炎组患者治疗后IL-6及IL-8及CRP水平明显降低,差异具有统计学意义(P<0.001),而与对照组相比差异无统计学意义(P>0.05)。结论 IL-6及IL-8及CRP在细胞性肺炎患者中的检测有助于患者病情的早期诊断及疗效评估。

Objective To discuss the levels of interleukin-6 （IL-6）, interleukin-8 （IL-8） and C-reactive protein （CRP） of patients with bacterial pneumonia and their clinical significance. Methods 120 patients with bacterial pneumonia in our hospital during May 2012 and January 2014 were enrolled, with 80 healthy people as the con- trols. The blood samples were obtained to detect the levels of IL-6, IL-8 and CRP before and after treat- ment. Results The levels of IL-6, IL-8 and CRP in patients with bacterial pneumonia were significantly higher than those in control group with a statistically significant difference （P 〈 0. 001 ）. The levels of IL-6, IL-8 and CRP of patients were significantly lower after treatment （P 〈 0. 001 ）, while the difference wasn＇t statistically sig- nificant compared with those in control group （ P 〉 0. 05 ）. Conclusion The detection of IL-6, IL-8 and CRP is helpful for early diagnosis and therapy assessment in patients with bacterial pneumonia.