P16表达与宫颈病变的相关性及临床意义

Correlation between P16 expression and cervical lesions and the clinical significance

目的:探讨P16在不同宫颈病变组织中的表达及在临床诊断中的应用价值。方法:选择慢性宫颈炎19例,各级别宫颈上皮内瘤变(CIN)89例(CINⅠ35例,CINⅡ30例,CINⅢ24例)及宫颈鳞状细胞癌7例,采用免疫组化技术检测P16在各组患者的表达水平。结果:P16在慢性宫颈炎、CINⅠ、CINⅡ、CINⅢ及宫颈鳞状细胞癌组患者的阳性表达率分别为0.00%、40.00%、66.67%、70.83%、100.00%,随宫颈病变程度的升级P16蛋白的表达率及阳性表达强度均逐渐上升,差异有统计学意义(P<0.05)。结论:P16用于鉴别不同级别宫颈上皮内瘤变指异临床诊疗有重要价值。

Objective： To explore the expressions of P16 in various cervical lesions tissues and its application value in clinical diagnosis. Methods： Nineteen patients with chronic cervicitis,eighty- nine patients with cervical intraepithelial neoplasia（ CIN）（ 35 patients with CINⅠ,30 patients with CINⅡ,and 24 patients with CINⅢ）,and seven patients with cervical squamous cell carcinoma were enrolled in the study; immunohistochemical technology was used to detect the expression levels of P16 in different groups. Results： The positive expression rates of P16 in chronic cervicitis,CINⅠ,CINⅡ,CINⅢ,and cervical squamous cell carcinoma were 0. 00%,40. 00%,66. 67%,70. 83%,and 100. 00%,respectively. The expression rate and positive expression intensity of P16 increased gradually with the aggravation of cervical lesions,there were statistically significant differences（ P〈0. 05）. Conclusion： P16 is used to identify different grades of CIN,which has an important value in guiding clinical diagnosis and treatment.