血碱性磷酸酶、钙、磷测定对早产儿代谢性骨病的诊断价值

Diagnostic value of serum alkaline phosphatase,calcium,and phosphonium test for metabolic bone disease of prematurity

目的：探讨早产儿代谢性骨病（MBDP）的早期诊断标准及防治措施。方法：对2012年7月~2014年3月期间15例MBDP患儿的资料进行回顾性分析,并检测其生后4周时血碱性磷酸酶、血钙、血磷水平。结果：早产儿代谢性骨病的早期临床表现不典型,严重时可发生骨折,给早产儿的脏器功能和生长发育带来严重影响;观察组血碱性磷酸酶较对照组升高（P〈0.05）,血磷值较对照组降低（P〈0.05）,两组之间血钙值差异无统计学意义（P〉0.05）;MBDP的防治应以适量的钙、磷、维生素D的摄入为主。结论：早期检测早产儿血碱性磷酸酶、血磷值有助于MBDP的早期诊断,早期防治是改善患儿预后的有效方法。

Objective： To explore the early diagnostic criteria and preventive and treatment measures of metabolic bone disease of prematurity（ MBDP）. Methods： The data of 15 premature infants with MBDP was analyzed retrospectively in the hospital from July 2012 to March 2014. The levels of alkaline phosphatase（ ALKP）,calcium,and phosphonium at 4 weeks after birth were detected. Results： The clinical manifestations of MBDP at early stage were not typical. Bone fracture occurred in severe premature infants,which had a severe impact on organ function and growth and development of the premature infants. Compared with the control group,serum ALKP level increased and serum phosphorus level decreased in observation group（ P〈0. 05）. There was no statistically significant difference in serum calcium level between the two groups（ P〉0. 05）. Prevention and treatment of MBDP should be focused on adequate intakes of calcium,phosphorus,and vitamin D. Conclusion： Early detection of serum ALKP and phosphorus is helpful for early diagnosis of MBDP. Early prevention and treatment is an effective way to improve prognosis of the premature infants with MBDP.