支原体肺炎患儿血清中肺表面活性蛋白及CD分子含量的变化及临床意义

Levels of pulmonary surfactant protein and CD molecules in children with Mycoplasma pneumonia and their clinical significance

目的探讨肺炎支原体患儿血清中肺表面活性蛋白及CD分子含量的变化及临床意义。方法选择2013年9月至2014年9月间在本院接受住院治疗的168例支原体肺炎患儿作为观察组,另取同期在本院进行疫苗接种的正常儿童151例作为对照组,比较两组儿童的血清肺表面活性蛋白及CD分子含量差异。结果 (1)观察组患儿的血清肺表面活性蛋白A、B、C、D含量均明显高于对照组,差异具有统计学意义(P<0.05);(2)观察组患儿的血清CD11b、CD4+CD25+Treg水平高于对照组,CD19、CD4、CD4/CD8水平低于对照组,差异均具有统计学意义(P<0.05)。结论支原体肺炎患儿血清肺表面活性蛋白含量增高,CD分子表达紊乱,其水平变化可以指导临床治疗并判断患儿预后。

Objective To investigate the changes of serum pulmonary surfactant protein and CD molecules levels in children with Mycoplasma pneumonia and their clinical significance. Methods A total of 168 children of Mycoplasma pneumonia in our hospital from September 2013 to September 2014 were selected as observation group, and 151 children of vaccination in the same period were enrolled as the control group. The children＇s serum pulmonary surfactant protein and CD molecules content were compared between the two groups. Results （1） The levels of se-rum pulmonary surfactant protein A, B, C, D were significantly higher in the observation group than the control group （P〈0.05）;（2） The levels of serum CD11b, CD4＋CD25＋Treg in the observation group were significantly higher than those in the control group, while the levels of CD19, CD4, CD4/CD8 were significantly lower than the control group （P〈0.05）. Conclusion Children with Mycoplasma pneumonia have increased serum pulmonary surfactant protein levels and dis-ordered CD molecules expression, which can be used to guide clinical treatment and judge prognosis.