银屑病关节炎患者外周血转化生长因子β_1的检测及其临床意义

Detection and clinical significance of TGF-β_1 of patients with psoriatic arthritis

目的研究银屑病关节炎(Ps A)患者检测外周血转化生长因子β1(TGF-β1)的临床意义。方法将2009年3月至2013年3月在我院接受治疗的64例Ps A患者纳入观察组,另选同期在我院接受健康体检的志愿者64例作为对照组。在患者治疗前和治疗中,病情基本痊愈之后以及部分患者复发时(健康对照组则在常规体检时进行)对比两组受试者的TGF-β1及表皮生长因子(EGF)水平,分析不同银屑病面积和严重程度指数(PASI)评分的Ps A患者外周血TGF-β1及EGF水平,以及Ps A患者不同治疗时期的外周血TGF-β1水平。结果观察组患者的TGF-β1水平明显低于对照组,EGF水平明显高于对照组,差异均有统计学意义(P<0.05)。根据Spearman法分析相关性可知,随着PASI评分不断增加,Ps A患者TGF-β1水平随之降低,二者呈现为负相关(r=-0.873,P=0.000),但患者PASI评分增加的同时,EGF水平无明显变化,二者无明显相关性(r=0.218,P=0.964)。Ps A患者治疗中与治疗后的TGF-β1水平均明显高于治疗前的水平,PASI评分水平均明显低于治疗前的水平,差异均有统计学意义(P<0.05)。Ps A复发患者的TGF-β1及PASI评分水平与治疗前比较,差异均无统计学意义(P>0.05)。结论检测Ps A患者外周血TGF-β1可较好地反映其疾病进展情况,可用于评估其治疗疗效。

Objective To study the clinical significance of detecting TGF-β1 of patients with psoriatic arthri-tis （PsA）. Methods Sixty-four patients with PsA who were treated in our hospital between March 2009 and March 2013 were selected as the observation group. Another 64 volunteers who were received physical examination in our hospital at the same time were selected as control group. TGF-β1 and the level of epidermal growth factor （EGF） of two group before treatment, in treatment, after basic recovery and recurrence of some patients （healthy control group in regular examination） were compared to analyze TGF in peripheral blood, EGF levels of PsA patients with different psoriasis areas and psoriasis severity index （PASI） score, and TGF in peripheral blood in different treatment period. Results TGF-β1 lev-el in observation group was significantly lower than that in control group, and EGF was significantly higher than that in control group. The differences were statistically significant （P〈0.05）. Spearman correlation analysis showed that TGF-β1 in PsA patients was decreased with the increasing of PASI score, with negative correlation （r=-0.873, P=0.000）. There was no significant change in EGF levels when patients’PASI score was increasing, which had no signif-icant relationship between them （r=0.218,P=0.964）. TGF-β1 of PsA patients in treatment and after treatment were both significantly higher than that before treatment, and PASI score were both lower than that before treatment. The differences were statistically significant （P〈0.05）. The difference of TGF-β1 and PASI scores of PsA recurrent patients was not statistically significant compared with that before treatment （P〉0.05）. Conclusion Detection of TGF-β1 in peripheral blood of PsA patients can better reflect progression of disease, which can be used to evaluate the curative ef-fect of treatment.