不同基因型沙眼衣原体感染与自然流产相关性分析

Correlation between different genotypes of Chlamydia trachomatis infection and spontaneous abortion

目的探讨不同基因型沙眼衣原体(CT)感染与自然流产之间的相关性。方法选择390例自然流产患者为观察组,155例正常妊娠孕妇为对照组,对比两组孕产妇CT感染率,并分析两组CT感染基因型之间的差异。结果观察组CT感染率为5.64%(22/390),明显高于对照组的1.29%(2/155),差异有统计学意义(P<0.05)。观察组CT感染22例(5.64%),其中单纯D型3例(13.6%),单纯E型7例(31.8%),单纯F型5例(22.7%),混合型7例(31.8%);对照组CT感染2例(1.29%),单纯F型1例(50%),混合型1例(50%).两组不同基因型CT感染率比较差异无统计学意义(P>0.05)。结论沙眼衣原体感染与自然流产有着密切关系,且以E、D、F三种基因型为主,因此对于上述基因型沙眼衣原体感染孕产妇应合理使用敏感性药物进行早期干预,并加强孕期胚胎发育监测,以降低不良妊娠结局发生率。

Objective To discuss the correlation between different genotypes of Chlamydia trachomatis （CT） infection and spontaneous abortion. Methods A total of 390 patients with spontaneous abortion were selected as the observation group, and 155 normal pregnant women were enrolled as the control group. Then the infection rate of CT and the genotype were compared between the two groups. Results The infection rate of CT in the observation group was 5.64%（22/390）, significantly higher than 1.29%（2/155） in the control group （P〈0.05）. Among the 22 cases of CT infection in the observation group, there were 3 cases （13.6%） of genotype with simple D type, 7 cases （31.8%） with simple E type, 5 cases （22.7%） with simple F type, and 7 cases （31.8%） with mixed infection. Among the 2 patients with CT infection in the control group, there were 1 case （50%） of genotype with simple F type and 1 case （50%） with mixed infection. There was no significant difference in the infection rate of different genotypes between the two groups （P〉0.05）. Conclusion There is a close relation between CT infection and spontaneous abortion, mainly infec-tion with E, D, F genotype. Pregnant women with CT infection should use drugs rationally for early intervention and strengthen the monitoring of embryonic development during pregnancy, in order to reduce the incidence of adverse pregnancy outcome.