卵巢外腹膜浆液性乳头状癌24例临床病理研究

A clinicopathological study on 24 cases of extraovarian peritoneal serous papillary carcinoma

目的探讨卵巢外腹膜浆液性乳头状癌(EPSPC)的临床和病理特点。方法回顾性分析2000-2012年我院收治的24例EPSPC患者及90例卵巢浆液性乳头状癌(OPSC)患者的临床和病理资料。结果 EPSPC患者的临床特征与OPSC相似。免疫组化结果显示,EPSPC患者的雌激素受体(ER)、孕激素受体(PR)及P53表达阳性率分别为25%、37.5%和33.3%,明显低于OPSC患者的66.7%、80%和65.6%,差异均有统计学意义(P<0.05)。结论 EPSPC患者的临床特点及组织学特征与OPSC相似,ER、PR、P53检测可为两者的鉴别诊断提供一定的依据,而卵巢无或仅微小浸润仍是目前区分两者的主要标准。

Objective To study the clinicopathological features of extraovarian peritoneal serous papillary carcinoma （EPSPC）. Methods The clinicopathological data of 24 patients of EPSPC and 90 patients of ovarian papil-lary serous carcinoma （OPSC） treated in our hospital from January 2007 to December 2012 were retrospectively ana-lyzed. Results The clinical features of EPSPC were similar to those of OPSC. The expressions of estrogen receptor （ER）, progesterone receptor （PR） and P53 in EPSPC （25%, 37.5%and 33.3%, respectively） were significantly lower than those in OPSC （66.7%, 80%and 65.6%, respectively） （P〈0.05）. Conclusion The clinical and histological char-acteristics of EPSPC are similar to those of OPSC. ER, PR and P53 may be useful markers for distinguishing EPSPC from OPSC, but the ovarian without infiltration or with slight infiltration only is still the main criterion.