超声介入瘤内注射无水酒精治疗原发性肝癌近期复发危险因素

The recurrent risk factors of ethanol injectio n by interventional ultrasound on treatment of primary liver cancer

目的：探讨超声介入瘤内注射无水酒精治疗原发性肝癌后近期复发的危险因素。方法前瞻性收集我院2007年1月—2011年12月73例超声介入瘤内注射无水酒精治疗原发性肝癌患者的临床资料，利用单因素回归分析超声介入瘤内注射无水酒精治疗原发性肝癌的相关因素，然后用多元回归分析法对相关因素进行分析，确定其近期复发危险因素。结果单因素分析发现：患者的性别、年龄、血清乙肝HBsAg阳性阴性、肿瘤部位、肿瘤数目组间的生存率差异无统计学意义。肿瘤大小、血清AFP水平、有无门脉癌栓形成、肝功能（ Child）分级、肿瘤分化程度、肿瘤不同转移部位之间生存率差异有统计学差异。经多因素分析及逐步回归结果显示，肝功能（ Child）分级、肿瘤分化程度、肿瘤转移、门脉癌栓是预后显著相关的因素（卡方检验，χ^2＝47．763，P＜0．01；似然比检验，χ^2＝450．546，P＜0．01）。结论肝功能（ Child）分级、肿瘤分化程度、肿瘤转移和门脉癌栓是超声介入后近期复发的危险因素。

Object ive To find related risk factors after PEIT under ultrasound .Methods We collected the data of 73 clinical PEIT cases from January 2007 to December 2011 .Univariate analysis found the related risk factors of PEIT.Multivariate analysis identified the independent risk factors .Results Single factor analysis showed that the differences between groups of patient′s sex,age,the positive and negative of serum HBsAg ,tumor location,tumor number in survival rates were not statistically significant;the differences in groups of tumor size , serum AFP levels,with or without portal vein tumor thrombus ,liver function（Child）grade,tumor type in survival rates were significant differences .Multivariate and stepwise regression analysis showed that liver function （ Child） grade,tumor type,tumor metastasis,portal vein thrombosis were factors relevant to prognosis ;all chi-square test,χ^2=47.763,P〈0.01;likelihood ratio test χ^2=450.546 ,P〈0.01.Conclusion liver function （ Child-pugh grade）,pathological type of tumors,tumor′s metastasis,emboli in portal vein are the risk factors after PEIT .