非小细胞肺癌放化疗后局部复发再程放疗的研究进展

Progresses on reirradiation for locally recurrence of non-small-cell lung cancer patients after radio-therapy and chemotherapy

非小细胞肺癌放化疗后的复发率较高，再程治疗的主要手段是放疗、化疗及放化综合治疗等。其治疗目的在于提高局部控制率的同时延长生存期。再程放疗对于治疗局部复发的非小细胞肺癌是可行的，治疗方法安全，能较好地提高患者生活质量。大多数患者可以耐受，有良好的近期疗效，未见严重的近期放射性损伤，但是晚期放射性损伤及远期疗效尚有待进一步研究。本文就非小细胞肺癌放化疗后局部复发再程放疗的作用及其相关临床研究进展进行综述。

The recurrence rate of non -small cell lung cancer （ NSCLC） patients after radiotherapy and chemotherapy have been increasing .The therapy scheme consists of reirradiation、chemotherapy、and chemoradio-therapy,with the purpose of improving the local control and prolonging the survival time .Reirradiation is feasible for locally recurrence of non -small-cell lung cancer patients , treatment is security and could better improve quality of life in patients .The majority of patients are tolerable and have better short -term efficacy , No severe short term radiation induced injury is observed .But the long term radiation induced injury and long term efficacy need further investigation .In the present paper ,we review the roles of reirradiation for locally recurrence of non -small-cell lung cancer patients after radiotherapy and chemotherapy and the progress in clinical research .