我院2013年住院患儿超说明书用药情况调查

Off-Label Drug Use of Hospitalized Children in Pediatric Wards of Our Hospital in 2013

目的:回顾性调查2013年温州医科大学附属育英儿童医院住院患儿超说明书用药情况,为了解全国儿科超说明书用药现状和制订超说明书用药政策提供数据支持。方法:分层随机抽取我院2013年住院患儿的用药医嘱和出院带药医嘱,依据药品说明书判断是否为超说明书用药,并分析超说明书用药类型及各科室超说明书用药情况等。结果:共抽取住院患儿443例,分析医嘱4 373条,涉及315种药物,按病例数、医嘱分类超说明书用药发生率分别为95.26%和40.48%;超说明书用药类型主要为日总量超说明书(24.65%)、单次剂量超说明书(21.52%)和频次超说明书(15.92%)。结论:温州医科大学附属育英儿童医院住院患儿超说明书用药较常见,反映出儿科临床医师用药不规范及药品说明书中儿科用药信息严重缺乏。

Objective： To retrospective survey the off-label drug use in pediatric wards of the Yuying Children＇ s Hospital of Wenzhou Medical University in 2013, so as to provide baseline data for getting acquainted with the extent of off-label drug use in pediatrics in China, and for making policies of off-label drug use. Methods： The stratified random sampling was conducted to select medical advice and discharge medication for hospitalized children in pediatric wards in 2013. According to drug instructions, the off-label drug use of prescriptions of all selected children was analyzed. Results： The total of 443 children were selected, and 4,373 prescriptions involved 315 drugs were analyzed. The rate of off-label drug use was 95.26% and 40.48% in case load and classification of prescriptions respectively. The main categories of off-label drag use were everyday total dosage （24.65%）, single dosage （21.52%） ,and frequency （15.92%）. Conclusion： The off-label drug use in pediatric wards is common in Yuying Children＇s Hospital of Wenzhou Medical University, pediatrician drug use is out of standardization, and the lack of drug instructions in pediatric information.