心血管疾病与DNA甲基化关系研究进展

Advances in association of DNA methylation with cardiovascular disease

DNA甲基化是一个长期、稳定的表观遗传修饰,可以改变细胞核内DNA与转录装置的结合能力,进而调节基因信息的表达。心血管疾病是危害人类健康的主要疾病,其发生、发展机制仍不明确。本文讨论了DNA甲基化在动脉粥样硬化、高血压病、心力衰竭等疾病发生、发展方面的相关作用机制。

DNA methylation is a long-term and stable epigenetic modification of genes, which can regulate the expression of gene through changing the ability of DNA in combining with transcription apparatus. Cardiovascular diseases are the main diseases that endanger human＇s health, up to now the pathogenesis of cardiovascular diseases is still not clear. This review focuses on the role of DNA methylation in major cardiovascular diseases such as hypertension, coronary artery disease, heart failure and so on, which will help us to understand such diseases and will lead to new approaches to the prevention and clinical treatment of them.