二仙汤加减治疗绝经后女性骨量减少32例临床观察

Clinical observation of Erxian decoction on menopause women with bone mass loss

目的观察二仙汤加减治疗绝经后女性骨量减少的临床疗效。方法选择密云地区女性绝经后骨量减少患者64例,随机分为2组。治疗组32例,采用二仙汤加减口服治疗;对照组32例,采用碳酸钙D3口服治疗。2组均治疗1年为1个疗程。观察2组临床证候疗效、中医症状积分、骨密度T值变化以及安全性。结果治疗组愈显率93.75%,对照组愈显率65.63%,2组愈显率比较差异有统计学意义(P<0.01),治疗组疗效优于对照组。2组治疗前后症状积分比较及治疗前后症状积分差值比较差异均有统计学意义(P<0.01),治疗组症状积分改善情况优于对照组。2组治疗前后骨密度T值及治疗前后骨密度T值差值比较差异均有统计学意义(P<0.05),治疗组骨密度T值增加情况优于对照组。2组均无不良事件发生。结论二仙汤加减治疗绝经后女性骨量减少能有效改善临床症状,并可增加骨密度,降低骨质疏松症发病率。

Objective To observe the clinical effects of Erxian decoction on menopause women with bone mass loss.Methods 64 postmenopausal women with bone mass loss of Miyun area were randomly divided into two groups.32 patients in treatment group were treated by Erxian decoction .32 patients in control group were treated by oral calcium carbonate D 3 .The course was one year in two groups .The clinical syndrome curative effects,TCM syn-drome score,bone mineral density （BMD） and security were observed in two groups .Results The cure and obvious effective rate in treatment group （93.75%） was superior to that in control group （65.63%,P 〈0.01）.There were significant differences between before and after treatment on syndrome score and the syndrome score difference in two groups （P 〈0.01）.The improvement of syndrome score in treatment group was superior to that in control group . There were significant differences between before and after treatment on T -score of BMD and the T -score difference in two groups （P 〈0.05）.The T -score added value in treatment group was superior to that in control group .There were no adverse events in two groups .Conclusion Erxian decoction can effectively improve the clinical symptoms of menopause women with bone mass loss ,increase bone mineral density,decreased osteoporosis incidence .