A、B期原发性肝癌患者证候特点初探

Preliminary study of the syndrome characteristics on A,B period of primary liver cancer

目的对97例A、B期原发性肝癌(PLC)患者中医证候分布特点进行归纳总结,为分期辨证论治PLC进行初步探讨。方法通过让97例PLC患者填写《原发性肝癌的中医证候调查问卷》进行统计,应用SPSS 17.0软件进行证候、症状分布统计,并初步探索证候分布与相关理化指标的对应关系。结果 A、B期PLC单一证候以脾虚证(41.9%)、气滞证(23.2%)及湿热证(22.3%)为主,2种单一证候构成的复合证以脾虚+湿热证(24.7%)、气滞+脾虚证(20.6%)为主,3种单一证候构成的复合证以气滞+脾虚+湿热证为主,其症状评分及丙氨酸氨基转移酶(ALT)、血清甲胎蛋白(AFP)数值均高于脾虚+湿热证、气滞+脾虚证。结论 A、B期PLC以复合证候多见,形成以脾虚为本虚,气滞与湿热为邪实的基本病机,随着邪实的加剧,病情进一步加重。

Objective To summarize the distribution characteristics of traditional Chinese medicine （TCM） syndrome on A,B period of primary liver cancer （PLC）,for the preliminary study of the stage and treatment based on syndrome differentiation of PLC.Methods The data of ＆lt;The TCM syndrome of PLC questionnaire ＆gt;which comple-ted by 97 PLC patients were analyzed.The distributions of syndrome and symptom were analyzed by SPSS 17.0.The correspondence between TCM syndrome distribution and relating physical and chemical indicators were preliminary in -vestigated.Results The type of spleen -deficiency （41.9%）, qi -stagnation （23.2%） and damp -heat （22.3%） were the main single syndrome of A ,B period of PLC.The syndrome of spleen -deficiency ＋damp -heat （24.7%） and qi -stagnation ＋spleen -deficiency （20.6%） were the main two composites syndrome of A ,B peri-od of PLC.The syndrome of qi -stagnation ＋spleen -deficiency＋damp -heat was the main three composites syn-drome of A,B period of PLC,and its symptom score and the level of ALT ,AFP were higher than those of the spleen -deficiency ＋damp -heat type and the qi -stagnation ＋ spleen -deficiency type.Conclusio n The composites syndrome was the most frequent type on A ,B period of PLC.The basic pathogenesis takes spleen -deficiency as orig-inal cause,qi -stagnation and damp -heat as pathogenic factors.As the pathogenic factor prevail ,the illness even worse.