比较地特胰岛素和甘精胰岛素分别联合门冬胰岛素治疗2型糖尿病的疗效

Comparisons of curative effects between insulin detemir and insulin glargine in combination with insulin aspart in the treatment of type 2 diabetes mellitus

目的对比地特胰岛素和甘精胰岛素分别联合门冬胰岛素治疗2型糖尿病的疗效。方法 68例2型糖尿病患者随机分为两组,每组34例。对照组采用甘精胰岛素与门冬胰岛素联合治疗方案,观察组采用地特胰岛素与门冬胰岛素联合治疗方案,观察两组治疗效果。结果观察组空腹血糖指数、餐后2 h血糖指数及糖化血红蛋白(Hb A1c)水平均明显低于对照组(P<0.05)。观察组血糖达标率及低血糖率分别为88.2%和2.9%,明显优于对照组(P<0.05)。两组胰岛素用量对比,差异无统计学意义(P>0.05)。结论在2型糖尿病临床治疗方案中,地特胰岛素与门冬胰岛素联合用药方案效果确切,可有效控制血糖波动,减少低血糖事件的发生,值得推广应用。

Objective To compare the curative effects between insulin detemir and insulin glargine in combination with insulin aspart in the treatment of type 2 diabetes mellitus. Methods A total of 68 of patients with type 2 diabetes mellitus were randomly divided into two groups, with 34 cases in each group. Control group received combined treatment by insulin glargine and insulin aspart, and observation group received combined treatment by insulin detemir and insulin aspart. Curative effects of the two groups were compared. Results The observation group had obviously lower levels of fasting blood glucose, 2 hour postprandial blood glucose, and glycosylated hemoglobin（Hb A1c） than the control group（P〈0.05）. The observation group had blood glucose standard rate and hypoglycemia rate as 88.2% and 2.9%, which were much lower than those in the control group（P〈0.05）. The difference of insulin dosage between the two groups had no statistical significance（P〉0.05）. Conclusion Combination of insulin detemir and insulin aspart in treatment of type 2 diabetes mellitus can provide precise effect. This method can effectively control blood glucose and reduce incidence of hypoglycemia events, and it is worthy of promotion and application.