成人外伤性癫痫的高危因素分析

Analysis of risk factors for adult traumatic epilepsy

目的探究成人外伤性癫痫(Posttraumatic epilepsy,PTE)发生的高危因素,并针对主要因素进行治疗。方法选择2012年1月至2013年12月,在本院接受治疗的颅脑损伤病患319例。其中并发PTE病患78例,记为观察组;其余未出现癫痫症状的病患241例记为对照组。收集两组病患的年龄、性别、颅脑损伤严重程度、格拉斯哥昏迷评分(Glasgow Coma Scale,GCS)评分以及颅脑损伤类型,并记录其他临床表现,进行相应的对比和分析。结果在319例颅脑损伤病患中出现PTE症状占24.45%(78/319),且晚期癫痫病患更多,达到83.33%(65/78)。再经过Logistic回归分析显示颅脑重度损伤、硬脑膜破裂、大脑皮层损伤以及凹陷性颅骨骨折等因素,是导致PTE并发症的主要因素(P<0.05)。结论 PTE的发生受颅脑损伤程度、硬脑膜是否破裂等影响。因此,颅脑损伤的临床治疗中应根据这些高危因素对PTE并发症作出相应的预防措施和有效的治疗。

ObjectiveTo explore the high-risk factors in adult traumatic epilepsy （posttraumatic epilepsy, PTE）, and the treatment.Methods 2012 January to 2013 December in our hospital 319 cases of craniocerebral injury patients was included. 78 cases with PTE were divided into the observa-tion group,. The rest 241 cases with no epilepsy were divided into control group.The age, gender, severity of craniocerebral injury, Glasgow coma score （GCS） and the types of brain injury, and other clinical manifestations were recorded and compareded.ResultsThe rate of PTE was 24.45% （78/319）, and the rate of late epileptic in the observation group was 83.33% （65/78）. The Logistic regression analysis showed that craniocerebral severe injury, dural laceration, cerebral cortex injury and depressed skull fractures were the main factors that lead to the complication of PTE （P〈 0.05）.ConclusionCraniocerebral se-vere injury, dural laceration, cerebral cortex injury and depressed skull fractures were the main factors that lead to the complication of PTE.