不同剂量纳洛酮治疗中重度酒精中毒的效果观察

Study of Naloxone Dose Effect on the Treatment of Alcohol Intoxication

目的观察不同剂量纳洛酮治疗中重度酒精中毒的临床疗效。方法将收治的100例酒精中毒患者随机分为对照组和观察组1、2、3，每组25例。对照组采取10％葡萄糖补液、吸氧、维持电解质平衡等常规治疗；观察组1、2、3分别给予0．8mg、1．2mg、1，6mg纳洛酮静脉注射治疗。观察各组治疗后症状消失和清醒时间、临床疗效。结果治疗后症状消失和清醒时间观察组1、2、3要明显短于对照组，且与纳洛酮的剂量有关（随剂量增大，症状消失和清醒时间缩短）；治疗后有效率对照组为72．0％，观察组1、2、3分别为88．0％，88．0％，96．0％，观察组明显高于对照组，差异具有统计学意义。结论较大剂量纳洛酮治疗中重度酒精中毒具有较好疗效。

Objective To observe the efficacy of naloxone in the treatment of alcohol intoxication. Methods 100 cases accepted by our hospital were selected and randomly divided into the control group 1,2,3 and the treatment group 1,2,3, each group containing 25 eases. In control group, routine treatments were provided, such as：supply of 10% glucose solution and oxygen, maintaining the balance of electrolyte and etc. The treatment group 1,2,3 were given 0.8 rag, 1.2 mg, 1,6 nag of naloxone based on the routine treatment.The cure time and curative effect of all the groups were observed. Results The therapeutic time and the cure time on the treatment group were much shorter than that on the control group and this observation was related to dose of naloxone（with the increasing dose usage, the cure time and symptom disappearance time became shorter）. After the treatment, the efficiency for control group was calculated at 72% ,while the efficiency for the treatment group 1,2,3 were up to 88.0% ,88.0%, 96.0% individually.The results in treatment group were obviously better than that in control group.The difference was statistically significant. Conclusion Relatively large dose of naloxone has obviously good effect on the treatment of acute alcohol intoxication.