蠕虫感染的免疫调节作用在诱导器官移植免疫耐受中应用价值的探讨

Value of established solid-organ transplant tolerance from experience of host immunomodulation with helminth infection

器官移植是重建器官功能的有效治疗方法,探寻无需长期服用免疫抑制的移植免疫耐受则是当前研究的热点。尽管几种诱导器官移植免疫耐受的方案已经被提出,甚至有些已应用于临床Ⅰ期试验,但这些免疫耐受诱导方案并没有达到理想的效果。本文从蠕虫感染能够长期调节宿主免疫反应的能力出发,从理论上阐明将蠕虫抗原用作调节受者免疫耐受的诱导的理论依据,提出受者免疫系统对供者移植器官的免疫耐受的形成需要供体抗原的刺激。输注供者脾脏来源的B淋巴细胞在联合蠕虫可溶性抗原作用下,让受者诱导供者特异性的免疫耐受具有重要的研究价值。

Organ transplantation is the effective method to replace the function of the patient failed organ. But it is very disappoint that recipients have to receive the long-term immunosuppression regimens for prevention of allograft rejection. To induce allograft immune tolerance without immunosuppressant is in great demand. Although several tolerance strategies for organ transplant have been proposed,even some has already been tested in the 1st clinical trial,these strategies haven＇t approached to ideal efficacy. Helminths are remarkably successful parasites to achieve immunological tolerance to host immune response. It is now well established that the parasites＇ success is the result of active immunomodulation of their hosts＇ immune response. We suggest that injecting B cells from donor spleen and helminth soluble antigens,recipient might become tolerance to donor organ,but not tolerated to other antigens. Research based on this approach has great translated value for future clinic practice.