小剂量甲巯咪唑联合加味知柏地黄汤治疗甲状腺功能亢进的成本及疗效分析

Analysis on Cost and Effect of Small Dose of Methimazole Combined Modified Zhibaidihuang Decoction in Treating hyperthyroidism

目的探讨小剂量甲巯咪唑联合加味知柏地黄汤治疗甲状腺功能亢进的治疗总成本及临床疗效。方法根据随机数字表法将80例患者随机分为治疗组和对照组,各40例。对照组应用常规剂量甲巯咪唑治疗,治疗组给予小剂量甲巯咪唑联合加味知柏地黄汤治疗,疗程均为6个月,且于治疗后随访6个月。结果治疗组总有效率为95.00%,显著高于对照组的72.50%(P<0.05);治疗后,治疗组总三碘甲状腺原氨酸(TT3),血清总甲状腺素(TT4),血清游离甲状腺素T3(FT3)、FT4水平显著低于对照组,促卵泡成熟激素(FSH)显著高于对照组(P<0.05);治疗过程中治疗组不良反应发生率为7.50%,显著低于对照组的27.50%(P<0.05);治疗后随访6个月治疗组复发率为2.50%,显著低于对照组的20.00%(P<0.05);治疗总成本治疗组显著低于对照组(P<0.05)。结论小剂量甲巯咪唑联合加味知柏地黄汤治疗甲状腺功能亢进的治疗总成本低,疗效显著,具有临床应用价值。

Objective To investigate the total cost and clinical effect of a small dose of methimazole combined Zhibaidihuang Decoction in treating hyperthyroidism. Methods 80 patients with hyperthyroidism were randomly divided into the treatment group and the control groups according to the random number table, 40 cases in each group. The control group received the methimazole therapy, while the treatment group was treated with small dose of methimazole combined with Zhibaidihuang Decoction. The treatment in the two groups lasted for 6 months and the 6-month follow-up was conducted after treatment. Results The total effective rate in the treatment group was 95. 00%, which was significantly higher than 72. 50% in the control group with statistical difference （ P ﹤ 0. 05 ）;the TT3, TT4, FT3 and FT4 levels after treatment in the treatment group were significantly lower than those in the control group, while the FSH level was significantly higher nthan that in the control group, the differences were statistically significant （ P ﹤ 0. 05 ）;the incidence rate of adverse reactions during treatment in the treatment group was 7. 50%, which was significantly lower than 27. 50% in the control group, the dif-ference was statistical significant （ P ﹤ 0. 05 ）; the relapse rate during 6-month follow-up after treatment in the treatment group was 2. 50%, which was significantly lower than 20. 00% in the control group, showing statistically significant difference between them （ P ﹤0. 05 ）;the total cost of the treatment group was significantly less than that in the control group with statistically significant difference （ P ﹤ 0. 05 ） . Conclusion Low-dose of methimazole combined with modified Zhibaidihuang Decoction in treating hyperthyroidism has low total cost, significant effect and important clinical research value.