益气化瘀颗粒治疗慢性舒张性心力衰竭气虚血瘀证的疗效观察

Effect of Yiqi Huayu Granules for Treatment of Chronic Diastolic Heart Failure with Qi Deficiency and Blood Stasis Syndrome

目的 观察益气化瘀颗粒治疗慢性舒张性心力衰竭气虚血瘀证的临床疗效及安全性.方法 将200 例心功能Ⅱ级~Ⅲ级的慢性舒张性心力衰竭患者随机分为两组.治疗组100 例予益气化瘀颗粒,每日1 剂（袋）,分早晚两次服用,对照组100 例予安慰剂（颗粒剂）,每日1 剂（袋）,分早晚两次服用.两组均予常规抗心力衰竭西药治疗,疗程均为2 个月,然后评价两组疗效及安全性.结果 两组治疗2 个月后,治疗组在心功能分级、心脏彩超舒张早期血流峰值速度（E 峰）与舒张中晚期血流峰值速度（A 峰）的比值（E/A）、下肢水肿指标改善方面与对照组比较均有统计学意义（P 〈0.05）;在气虚血瘀证候改善方面,治疗组与对照组总有效率分别为96.9%和69.9%,治疗组优于对照组（P 〈0.05）.结论 在常规西药治疗的基础上加用益气化瘀中药,是慢性舒张性心力衰竭治疗的有效选择,且具有安全性.初步证实慢性舒张性心力衰竭的发性与中医气虚血瘀病机具有相关性.

Objective To investigate the effect of Yiqi Huayu granules(YHG)for treatment of chronic diastolic heart failure with qi defi-ciency and blood stasis syndrome.Methods Two hundreds patients with heart function Ⅱ to Ⅲ level(LVEF≤45%)were randomly divided into two groups:Treatment group (n= 100)treated by YHG plus routine western medicine,and control group (n= 100) treated by placebo(granular)plus routine western medicine for 2 month.The clinical effect and safety were evaluated.Results There was statistical significance in improvement of heart function level,echocardiography E/A ratio and lower extremity edema between two groups(P<0.05).There was statistical significance in improvement of qi deficiency and blood stasis syndrome between two groups, the total effective rate was respectively 96.9% and 69.9% (P<0.05).Conclusion YHG plus routine western medicine was effective and safe in chronic diastolic heart failure with qi deficiency and blood stasis syndrome.