轻度认知障碍患者脑结构与功能网络变化的研究进展

Research Progress of Cerebral Structure and Functional Network Change in Patients with Mild Cognitive Impairment(review)

本文回顾影像学结合脑网络分析的方法对轻度认知障碍的研究。脑连接可以反映脑内信息的处理过程,既往研究表明人脑具有小世界属性,在阿尔茨海默病、轻度认知障碍中都会出现小世界属性改变,不同研究方式分析得出的具体改变形式有所不同,目前为止尚无统一标准。本文旨在描述脑网络分析方法对轻度认知障碍研究的现状,说明其对轻度认知障碍研究的重要性,以及这一新兴的跨学科结合探索研究的方法应用前景的广阔性。

This article reviewed the application of different kinds of imaging methods combined with the analysis of brain connectome in mild cognitive impairment. Previous studies demonstrated that the brain worked as the small-world network. In patients with Alzheimer＇s disease or mild cognitive impairment, the structure of small-world of network might be changed. According to the different methods, the trend of those changes might be different. This paper reviewed the current situation of the study in mild cognitive impairment through brain network analysis, and emphasized its importance and prospects.