基于共词分析法对于新生儿败血症的可视化研究

Visualized analysis of progress in neonatal septicemia in China through co-word analysis method

目的通过共词分析法建立国内新生儿败血症(NS)研究关键词的可视化共现网络,分析我国NS研究的发展趋势。方法本研究以"新生儿","败血症"为关键词,在中国生物医学文献数据库(CBM)和中国知网(CNKI)中及限定文献发表时间为1960年1月1日至2014年5月28日检索出符合本研究标准的1 719篇文献为研究对象。通过Endnote X6软件将其分为1960-1993年阶段、1994-2003年阶段和2004-2014年阶段,统计各阶段的核心关键词及其词频。利用Bicom 2对核心关键词建立共现矩阵,使用Ucinet 6.0绘制可视化网络。观察3个阶段间关键词及其词频的联系和变化。结果 3个阶段有关NS的发表文献数量分别为257,655,807篇,而发表NS相关文献的期刊共为401种,作者单位共为477家。通过共词分析法成功建立我国NS的研究发展可视化网络,直观反映我国NS研究发展情况。1960-1993年阶段主要为NS的临床认识阶段,1994-2003年阶段主要着重于NS的诊断和治疗,2004-2014年阶段主要致力于NS早期感染指标的筛选及耐药菌和抗菌药物研究。结论我国NS研究起步于1960年,至1994年后开始有极大的发展,在此期间国内NS的定义及诊断变迁与国际相一致。目前,NS的诊断性研究更注重于临床表现及早期感染指标的筛选。耐药菌及抗菌药物运用是NS治疗研究的热点之一,近10年来免疫疗法的研究数量有所下降,但是仍存在进一步研究价值。

Objective To study the progress of neonatal septicemia（NS）by using co-word and social network analysis in China,then build visualized network and predict the development trends in the future.Methods From January 1st 1960 to May 28 th 2014,a total of 1 719 articles about NS from China Biology Medicine（CBM）disc and Chinese National Knowledge Infrastructure（CNKI）were found out according to the keywords ＂ neonatal＂, ＂ septicemia＂.They were divided into stage 1960-1993,stage 1994-2003,stage2004-2014 by Endnote X6.The core-key words were taken out from 3stages and the co-occurrence matrix was built by Bicom 2.Then visualized network was drawn by Ucinet 6.0.The differences between core-key words frequency and its correlation were compared.Results The number of articles in 3stages were 257,655,807,respectively.They were published in 401 kinds of medical journals,and the number of author′s affiliation were 477.The visualized network of NS in China was successfully built,and it directly reflected the changes of hot topics in this field.The NS research at stage 1960-1993 were focus on its clinical recognition.Diagnosis and treatment of NS were much accounted at stage 1994-2003.The NS research at stage 2004-2014 mainly dedicated to early detection of infection index,drug-resistance bacteria and antibiotic application of NS.Conclusions The research of NS in China started in the 1960 s,and had made great progress after 1994.The definition and diagnosis of NS changes consistent with abroad.At present,the current diagnostic studies pay more attention to the clinical manifestations and early infection index selection,with the decline in the proportion of blood culture of bacteria.Antibiotic resistance research is one of the research hotspots in NS therapy,immunotherapy research has declined in the number of recent 10 years but still is of further study value.