多囊卵巢综合征与自身免疫性甲状腺炎的相关性研究

Correlation between polycystic ovary syndrome and autoimmune thyroiditis

目的探讨多囊卵巢综合征(PCOS)患者中自身免疫性甲状腺炎(AIT)的发生情况及其临床意义。方法选择2011年1月至2012年10月于广东省第二人民医院生殖医学中心就诊的116例PCOS患者为研究对象并纳入PCOS组(n=116)。选择同期于该院就诊的309例不孕患者为对照组(n=309)。本研究遵循的程序符合广东省第二人民医院人体试验委员会所制定的伦理学标准,得到该委员会批准,分组征得受试对象本人的知情同意,并与之签署临床研究知情同意书。两组患者年龄、月经周期等一般资料比较,差异无统计学意义(P>0.05)。采用化学发光免疫法检测两组患者月经第3天的性激素水平、血清甲状腺激素和甲状腺自身抗体水平变化。结果 1PCOS组患者月经第3天黄体生成素(LH)、睾酮水平显著高于对照组,并且差异有统计学意义(P<0.05)。2两组患者月经第3天血清游离三碘甲腺原氨酸(FT3)、血清游离甲状腺素(FT4)、促甲状腺激素(TSH)比较,差异无统计学意义(P>0.05)。PCOS组患者甲状腺过氧化物酶抗体(TGAb)、甲状腺球蛋白抗体(TPOAb)水平及TGAb>60 U/mL、TPOAb>60U/mL患者比例均显著高于对照组,并且差异均有统计学意义(P<0.05)。3PCOS组体质量指数(BMI)和甲状腺超声结果异常患者比例显著高于对照组,且差异有统计学意义(P<0.05)。结论 PCOS与AIT的发病密切相关。

Objective To explore the occurrence of autoimmune thyroiditis（AIT）in polycystic ovary syndrome（PCOS）patients and their clinical significance.Methods From October 2011 to October 2012,a total of 116 patients with PCOS were recruited in the study in the Second People′s Hospital of Guangdong Province as PCOS group（n=116）.Meanwhile 309age-matched infertile women without PCOS were chosen as control group（n=309）.The study protocol was approved by the Ethical Review Board of Investigation in Human Being of the Second People′s Hospital of Guangdong Province.Informed consent was obtained from each participants.There were no significant differences in general condition menstrual cycle and etc.between two groups（P〉0.05）.The levels of sex hormones,serum thyroid hormones and thyroid autoantibodies were detected by chemiluminescence immunoassay at the third day of menstrual period.Results ①The levels of luteinizing hormone（LH）and testosterone in the patients with PCOS were significantly higher than those of control group（P〈0.05）.②There were no significant differences of free triiodothyronine（FT3）,free thyroxine（FT4）,thyroid stimulating hormone（TSH）level between two groups（P〉0.05）.The levels of thyroid peroxidase antibody（TGAb）,thyroglobulin antibody（TPOAb）and the proportion of abnormal TGAb,TPOAb（〉60U/mL）in PCOS group were obviously higher than those of control group,and the differences were significant（P〈0.05）.③The levels of body mass index（BMI）and the proportion of thyroid abnormal ultrasound in PCOS group were higher than those of control group,and the differences were also significant（P〈0.05）.Conclusion PCOS is closely related to the onset of AIT.