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原因不明复发性自然流产发病机制的研究进展 被引量：7

Research progress of the pathogenesis of unexplained recurrent spontaneous abortion
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摘要 原因不明复发性自然流产(URSA)病因较为复杂,该病也是造成不孕的主要原因,成为临床诊疗的热点和难点问题。笔者拟就叶酸代谢酶基因突变、人类白细胞抗原(HLA)基因系统表达异常、辅助性T细胞(Th)1/Th2平衡失调、白细胞介素(IL)-18作用和精子因素等5个方面与URSA发病机制的相关研究进展综述如下。 The causes of unexplained recurrent spontaneous abortion（URSA）is extremely complicated,and URSA is the main cause of infertility.This review focuses on research progress of relationship between folate metabolism enzyme gene mutation,human leukocyte antigen（HLA）gene expression abnormalities,disorder of helper T cell（Th）1/Th2 balance,interleukin（IL）-18,sperm factor and the pathogenisis of URSA.
作者 刘绪义 陈晨 李俊强 李春梅
机构地区 四川大学华西第二医院妇产科 四川省眉山市妇幼保健院
出处 《中华妇幼临床医学杂志（电子版）》 CAS 2015年第3期119-122,共4页 Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
关键词 流产 习惯性 原因不明 发病机制 Abortion,habitual Unkown origin Pathogenesis
分类号 R714.21 [医药卫生—妇产科学]
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参考文献35

  • 1Kuon RI. Wallwiener LM. Germeyer A. et al. Establishment of a standardized immunological disagnostic procedure in RM patients[J]. I Reprod Immunol.2012.94(l) :55.
  • 2Guenther BD. Sheppard CA. Tran P. et al. The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia [J]. Nat Struct Biol.1999.6(4) :359-365.
  • 3Frosst Pv Blom HI. Milos R.et al. A candidate genetic risk factor vascular disease i a common mutation in methylenetetrahydrofolate reductase[J]. Nat Genet.1995.10(l) :111-113.
  • 4Siemianowicz K. Gminski I. Garezorz W. et al. Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms in patients with small cell and nonsrnall cell lung cancer[J]. Oncol Rep.2003.10(S) :1341-1344.
  • 5Kumar KS. Govindaiah V. Naushad SE. et al. Plasma homocysteine levels correlated to interactions between folate status and me methylenetetrahydrofolate reductase gene mutation in women with unexlained recurrent prenancy 10ss[J]. I Obstet Gynaecol , 2003.23 (1) : 55-58.
  • 6Mtiraoui N. Zammiti W. Ghazouani L. et al. Methylenetetrahydrofolate reductase C677T and A1298C polymorphism and changes in homocysteine concentrations in women with idiopathic recurrent prenancy lcsses[J]. Reproduction. 2006 .131( 2) : 395-401.
  • 7Ren A. Wang I. Memethylenetetrahydrofolate reductase C677T polymorphism and the risk of unexplained recurrent pregnancy loss: a meta-analysis[J]. Fertil Steril. 2006.86 (6) : 1716-1722.
  • 8Lin PT. Huang MC. Lee BI. et al . High plasms homocysteine is associated with the risk of coronary artery disease independent of methylenetetrahydrofolate reductase 6 77 C T gcnotypes[J]. Asia Pac I Clin Nutr.2008.17(2) :330-338.
  • 9Khandanpour N. Willis G. Meyer Fl. et al . Peripheral arterial disease and methylenetetrahydrofolate reductase (MTHFR) C6 77T mutations: a case-control study and meta-analysis[J]. I Vase Surg , 2009.49(3):711-718.
  • 10Miele O. Muresan M. Antal L. The influence of homocysteine and oxidative stress on pregnancy outcome[J]. J Med Life. 2012.22 (5) :68-73.

二级参考文献43

  • 1管立学,杜欣莹,王敬先,高丽,王瑞丽,李海波,王守训.PAI-1基因和MTHFR基因多态性与复发性早期自然流产的关系[J].中华医学遗传学杂志,2005,22(3):330-333. 被引量：16
  • 2任爱国,杨旭辉,李竹.同型半胱氨酸代谢与习惯性流产关系的研究进展[J].中国生育健康杂志,2005,16(6):374-377. 被引量：7
  • 3徐俐,刘肖曼,张红岩,赵晶,戚其玮,常云飞.亚甲基四氢叶酸还原酶、凝血因子Ⅴ和凝血酶原基因多态性与原因不明复发性早期流产的关系[J].中华妇产科杂志,2007,42(3):180-183. 被引量：19
  • 4左联富主编.流式细胞术与生物医学[M].沈阳：辽宁科学技术出版社,1996.65-98.
  • 5Payne SG, Smith SG, Davidge ST, et al. Death receptor/Apo-1/CD95 expressed by human placental trophoblasts dose not mediate apoptosis[J]. Biol Reprod,1999,60(5):1144-1150.
  • 6Hill JA, Bolgay K, Anderson DJ. T helper 1 type immunity to trophoblast in women with recurrent spontaneous abortion[J]. JAMA, 1995,273(24) : 1933-1936.
  • 7Judge TA,Tang A,Spain LM,et al.The in vivo mechanism of action of CTLA4Ig.J Immunol,1996;156(6):2294-2299.
  • 8Raghupathy R,Makhseed M,Azizieh F,et al.Maternal Th1-and Th2-type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortions.Cell Immunol,1999;196(2):122-130.
  • 9Khoury SJ,Akalin E,Chandraker A,et al.CD28-B7 costimulatory blockade by CTLA4Ig prevents actively induced experimental autoimmune encephalomyelitis and inhibits Th1 but spares Th2 cytokines in the central nervous system.J Immunol,1995;155(10):4521-4524.
  • 10Schweitzer AN,Sharpe AH.Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production.J Immunol,1998;161(6):2762-2771.

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中华妇幼临床医学杂志（电子版）
2015年 第3期

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