白细胞介素-28B rs12979860 T/C基因多态性与肝细胞癌易感性关系的Meta分析

Association between polymorphism of interleukin-28B rs12979860 T/C and susceptibility of hepatocellular carcinoma： a Meta-analysis

目的：探讨白细胞介素-28B（IL-28B）rs12979860 T/ C 基因多态性与肝细胞癌（HCC）易感性的关联。方法计算机检索 PubMed、EMBase、中国知网数据库、中国生物医学文献数据库、维普数据库及万方数据库，检索时间截至2014年9月30日，收集有关 IL-28B rs12979860 T/ C 基因多态性与肝细胞癌易感性的病例-对照研究。由2名研究者按照纳入和排除标准独立选择文献、提取资料，采用 Rev-Man 5.2和 Stata 12.0软件进行 Meta 分析。结果最终纳入6个病例-对照研究，包括1138例患者和955例对照。各遗传模型 Meta 分析结果显示，IL-28B rs12979860 T/ C 多态性与肝细胞癌易感性的关联性有统计学意义，与基因型 CC 及 CT ＋ CC 比较，基因型 TT 可增加人群罹患肝细胞癌的风险（TT ： CC：OR =2.26，95% CI 为1.40～3.64，Z =3.33，P =0.0009；TT ： CT ＋ CC：OR =1.90，95% CI 为1.23～2.93， Z =2.89，P =0.004）。种族来源的亚组分析结果显示，在白种人群中，IL-28B rs12979860 T/ C 多态性与肝细胞癌易感性存在显著相关性（TT ： CC：OR =2.06，95% CI 为1.22～3.47，Z =2.70，P =0.007；TT ：CT ＋ CC：OR =1.71，95% CI 为1.07～2.72，Z =2.23，P =0.03）。结论 IL-28B rs12979860 T/ C 基因多态性与肝细胞癌易感性相关，基因型 TT 可增加罹患肝细胞癌的风险。

Objective To explore the correlation between polymorphism of interleukin-28B（IL-28B） rs12979860 T/ C and susceptibility of hepatocellular carcinoma（ HCC）. Methods All eligible case-control studies published up to 2014-09-30 were identified by searching PubMed,EMBase,CNKI,CBM,VIP and WanFang databases. Two reviews independently identified the literature according to inclusion and exclusion criteria. Meta-analysis was performed using Rev Man 5. 2 and Stata 12. 0 software. Results A total of 6 stud-ies comprising 1 138 cases and 955 controls were finally included. Meta-analysis showed that IL-28B rs12979860 T/ C polymorphism was associated with the susceptibility of HCC. Compared with the genotype CC and CT ＋ CC,genotype TT increased the risk of suffering from HCC（TT vs CC：OR = 2. 26,95% CI：1. 40-3. 64,Z = 3. 33,P = 0. 000 9;TT vs CT ＋ CC：OR = 1. 90,95% CI：1. 23-2. 93,Z = 2. 89,P = 0. 004）. In stratification analysis by ethnicity,we observed that the polymorphism of IL-28B rs12979860 T/ C was associat-ed with the susceptibility of HCC among Caucasian populations（TT vs CC：OR = 2. 06,95% CI：1. 22-3. 47, Z = 2. 70,P = 0. 007;TT vs CT ＋ CC：OR = 1. 71,95% CI：1. 07-2. 72,Z = 2. 23,P = 0. 03）. Conclusion The polymorphism of IL-28B rs12979860 T/ C is associated with the susceptibility of HCC,genotype TT may increase the susceptibility to HCC.