PDCD5与肿瘤的临床相关性

Clinical relativity of PDCD5 with tumor

程序性细胞死亡因子5（PDCD5）是一种新的程序性细胞死亡调控基因。PDCD5表达广泛，进化保守，具有促进肺癌、肝癌等多种肿瘤细胞凋亡和抑制细胞增殖的效应。PDCD5在疾病情况下，特别是在肿瘤细胞中的表达明显下调，与肿瘤有着密不可分的临床相关性，对肿瘤的发现、诊断和治疗有很大的临床检验价值。

Programmed cell death 5（PDCD5）is a new kind of programmed cell death regulation and control gene. PDCD5′s expression is widespread,and evolution is conservative. PDCD5 has the effect of promo-ting a wide variety of tumor cells to apoptosis and inhibiting proliferation,such as lung cancer,liver cancer et al. Several laboratories′ discoveries show that PDCD5′s expression is significantly decreased when in some dis-ease cases,especially in tumor cases. PDCD5,which is related to the clinical relevance of the tumor,has a great clinical value of discovering,diagnosis and treatment of the tumor.