p70S6K1及4E-BP1蛋白在结直肠癌中的作用

The effect of p70S6K1 and 4EBP1 protein in colorectal cancer

磷脂酰肌醇激酶3-蛋白激酶B-雷帕霉素靶蛋白（mTOR）信号通路在结直肠癌的发生、发展中发挥重要的作用。mTORC1下游靶点是核糖体 S6蛋白激酶1（p70S6K1）和真核翻译起始因子-4E结合蛋白1（4EBP1），两者在蛋白质合成中起主要的调节作用。结直肠癌中 p70S6K1及4EBP1的异常表达成为关注的焦点。

The phosphatidylinositide-3-kinase（PI3K）/ protein kinase B（Akt）/ mammalian target of rapamycin（mTOR）pathway is recognized to have an important role in the development and progression of colo-rectal cancer（CRC）. The most extensively characterized downstream targets of mTORC1 are ribosomal protein S6 kinase 1（p70S6K1）and eukaryotic translation initiation factor（eIF）4E-binding protein 1（4EBP1）,both of which are crucial to the regulation of protein synthesis. The abnormal expression of p70S6K1 and 4EBP1 in CRC has become the focus of attention.