自发性荧光支气管镜检查对于肺癌患者的早期诊断价值

Early diagnostic value of autofluorescence bronchoscopy in patients with lung cancer

目的：探讨自发性荧光支气管镜（AFB）在肺癌早期诊断中的价值。方法分别应用 AFB及普通白光支气管镜（WLB）方法对708例患者进行检查，以病理结果为金标准进行分组，对肺癌高危因素进行分析，并对比2种方法的敏感性及特异性。结果708例患者中病理诊断为肺癌的372例，对病理良性组和病理恶性组进行年龄、性别及是否吸烟进行统计分析，高龄、男性、吸烟在病理恶性组比例均显著高于病理良性组（P 〈0.001）；AFB 与 WLB 对肺癌诊断的敏感性、特异性分别为98.9%、65.3%和90.8%、64.9%。AFB 在敏感性及特异性方面均显著高于 WLB。结论 AFB 在肺癌患者尤其是吸烟肺癌患者的早期诊断中具有重要临床应用价值。

Objective To evaluate the value of autofluorescence bronchoscopy （AFB）in early diagnosis of lung cancer.Methods Seven hundred and eight patients underwent both AFB and white light bronchoscopy （WLB）were divided into lung cancer group （n =372）and benign lesions group （n =336） according to pathological diagnosis,risk factors of lung cancer were analysed,and the sensitivity and specificity of AFB and WLB were compared.Results There were significant differences in age,sex,and smoking between two groups （P 〈 0.001 ）.The sensitivity and specificity of AFB for lung cancer diagnosis were higher than those of WLB （98.9% vs 65.3% and 90.8% vs 64.9%）.Conclusions AFB plays an important role in the early diagnosis of lung cancer,especially for the smokers.