正清风痛宁片联合非甾体抗炎药治疗骨关节炎疗效及安全性Meta分析

Efficacy of Zhengqingfengtongning Tablets and Non-Steroid Anti-Inflammatory Drugs Combination Therapy for Osteoarthritis: Meta-analysis

目的：评价正清风痛宁片联合非甾体抗炎药（non-steroid anti-inflammatory drugs，NSAIDs）治疗骨关节炎的临床疗效。方法计算机检索中国生物医学文献数据库、中国学术期刊全文数据库、中文科技期刊数据库、万方数据库、PubMed、EMbase，搜集正清风痛宁片联合 NSAIDs 与 NSAIDs 单药治疗骨关节炎的随机对照试验。中文检索词包括“正清风痛宁”、“非甾体抗炎药”、“青藤碱”、“骨关节炎”、“骨关节病”、“退行性关节炎”、“变性骨关节病”；英文检索词包括“zhengqingfengtongning”、“sinomenine”、“NSDIAs”、“osteoarthritis”。采用 Cochrance 系统评价方法评价纳入文献的质量，使用 Revman 5．2统计软件对纳入的文献进行 Meta 分析。结果共纳入4个随机对照试验，共516例患者。Meta 分析结果显示，正清风痛宁片联合 NSAIDs 显效率（65．1％比45．5％，OR ＝2．22，95％CI 为1．49～3．29，P ＜0．0001）和总有效率（93．0％比76．1％，OR ＝3．82，95％CI 为2．22～6．56，P ＜0．0001）优于单用 NSAIDs。正清风痛宁片联合 NSAIDs 不良反应发生率（19．5％）与单用 NSAIDs（11．9％）差异无统计学意义（OR ＝1．93，95％CI 为0．92～4．02，P ＝0．08）。结论正清风痛宁片联合 NSAIDs 作为一种治疗尝试，对骨关节炎治疗的进一步研究具有一定启示作用。

Objective To evaluate the clinical efficacy of Zhengqingfengtongning tablets plus non-steroid anti-inflammatory drugs （NSAIDs）for patients with osteoarthritis.Methods CBM,CNKI,VIP database, Wanfang database,PubMed and EMbase were retrieved by computer for randomized controlled trials of Zhengqingfengtongning tablets combined with NSAIDs for osteoarthritis,compared with NSAIDS only.The quality of literatures was evaluated based on the Cochrance system and meta-analyzed by using Revman5.2 version.Results A total of 4 trials involving 516 patients were included.The meta-analysis showed that the significant efficacy （65.1% vs.45.5%,OR =2.22,95% CI：1.49-3.29,P〈0.000 1 ）and total efficacy （93.0% vs.76.1%,OR =3.82,95%CI：2.22-6.56,P 〈0.000 1）of Zhengqingfengtongning tablets plus NSAIDs for osteoarthritis were better than the NSAIDs only.There was no statistical significant＆amp;nbsp;difference in the rate of adverse drug reaction between Zhengqingfengtongning tablets plus NSAIDs and NSAIDs only （19.5% vs.11.9%, OR = 1.93,95% CI： 0.92-4.02, P =0.08 ）. Conclusion Zhengqingfengtongning tablets combined with NSAIDs has some efficacy on the treatment of osteoarthritis and has shed a light on the further research on the treatment of osteoarthritis.