难溶性中药姜黄素自乳化微球的制备及性质考察

Preparation and invitro release characteristics of curcumin in self-emulsifying microsphere

目的制备姜黄素自乳化微球,以提高姜黄素的水溶性,进而提高其生物利用度。方法利用溶解度实验和伪三元相图的方法筛选自乳化处方,利用单纯型网格法进行处方优化,并对制备的自乳化微球进行体外性质考察。结果制备的自乳化微球的最大载药量为71.32mg/g,包封率为44.31%,平均粒径为11.33μm,在3种递质中的释放量均超过80%。结论所制备的姜黄素自乳化微球载药量高,包封率、粒径符合要求,能够显著提高姜黄素的释放度。

Objective To prepare curcumin album in self-emulsifying microsphere and study its release characteris-tics in vitro. Methods The contents of curcumin was measured by HPLC. Pseudo-ternary phase diagrams were constructed to identify the efficient self-emulsification region. In vitro dissolution determination was carried out. Results The largest drug loadings of self-emulsifying microsphere was 71. 32mg/g,the encapsulation efficiency was 44. 31%,the average grain diame-ter was 11. 33μm,and the emission capacity was over 80% in three different mediums,respectively. Conclusion The self-microemulsifying microsphere can be successfully formulated with high drug loading rate and dissolution.