单磷酸阿糖腺苷治疗小儿疱疹性口腔炎的疗效观察

Clinical effect of vidarabine monophosphate in the treatment of children with vesicular stomatitis

目的探讨磷酸阿糖腺苷治疗小儿疱疹性口腔炎的临床疗效。方法选取烟台市妇幼保健院2012年1月—2013年10月收治的疱疹性口腔炎的患儿164例,随机分为观察组75例和对照组89例。观察组给予单磷酸阿糖腺苷治疗,对照组给予利巴韦林治疗,比较两组患儿的退热时间、疱疹消失时间及临床疗效。结果观察组总有效率(94.6%)高于对照组(77.5%),疱疹消退时间及退热时间短于对照组,差异有统计学意义(P<0.05)。结论单磷酸阿糖腺苷治疗小儿疱疹性口腔炎的疗效确切。

Objective To study the clinical efficacy of vidarabine monophosphate in the treatment of children with ve-sicular stomatitis. Methods In Maternal and Child Health Hospital of Yantai from January 2012 to October 2013,164 children with vesicular stomatitis were randomly divided into observation group（75 cases） and control group（75 cases）. Observation group were treated with vidarabine monophosphate,control group were treated with ribavirin,time of fever relieving,disappear-ance time of herpes and clinical efficacy of the two groups were compared. Results Total effective rate of observation group was higher than control group,time of fever relieving and disappearance time of herpes were shorter than control group,the differ-ences were statistically significant（ P〈0. 05）. Conclusion Clinical efficacy of vidarabine monophosphate is sure in the treat-ment of children with vesicular stomatitis.