多索茶碱治疗老年肺功能下降患者的疗效观察

The curative effect observation of doxofylline on senile patients with pulmonary function decline

目的观察多索茶碱对老年肺功能下降患者的临床疗效。方法将134例肺功能下降的老年患者随机分为观察组和对照组各67例。在常规内科治疗的基础上,观察组加用多索茶碱治疗,对照组给予氨茶碱治疗,比较2组的治疗效果和不良反应发生情况。结果观察组治疗总有效率为89.55%高于对照组的67.16%,差异有统计学意义(P<0.05)。治疗前2组各项肺功能指标差异均无统计学意义(P>0.05);2组治疗后各项肺功能指标均较治疗前显著升高,且观察组升高幅度大于对照组,差异均有统计学意义(P<0.05)。2组患者治疗后血气分析各指标均较治疗前有所改善(P<0.05),且观察组治疗后PCO2低于对照组,PO2、Sa O2高于对照组(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.01)。结论多索茶碱治疗老年肺功能下降效果较好,不良发生发生率较低,安全性较好。

Objective To observe the curative effect of doxofylline on senile patients with pulmonary function de -cline.Methods 134 senile patients with pulmonary function decline were randomly divided into observation group and control group,and 67 cases of each.On the basis of conventional therapy ,the observation group was given doxofylline treatment ,and the control group was given aminophylline treatment .Then compared the efficacy and adverse reaction of the two groups .Re-sults The total effective rate of observation group was 89.55%,which was higher than 67.16% in the control group,the difference was statistically significant （P〈0.05）.Before the treatment,the differences between the pulmonary function indexes of two groups had no statistical significance （P〉0.05）;After treatment,the pulmonary function indexes of the two groups were significantly increased ,and the observation group increased more than the control group ,the differences were statistically signif-icant（P〈0.05）.After treatment,the blood gas analysis the indexes of two groups were improved （P〈0.05）,and the PCO2 of observation group was lower than that of the control group ,PO2,SaO2 were higher than that of the control group （P〈0.05）;The incidence of adverse reaction in observation group was lower than that of the control group ,the difference was statistically significant（P〈0.01）.Conclusion Doxofylline is a effictive and safety treatment to senile patients with pulmonary function decline .