长效干扰素α治疗176例慢性病毒性肝炎的不良反应分析

Analysis of adverse drug reactions associated with pegylated interferon-α therapy against chronic viral hepatitis in 176 patients

目的:了解长效干扰素在慢性病毒性肝炎抗病毒治疗过程中出现的常见不良反应及罕见不良反应。方法:对近3年我院慢性病毒性肝炎患者在使用长效干扰素抗病毒治疗的过程中出现的药物不良反应进行回顾性调查分析。结果:176例患者共出现不良反应620例次,其中发热(56.8%)、肌肉酸痛(36.4%)、白细胞减少(81.8%)及流感样症状(44.3%)为长效干扰素α的常见不良反应;罕见的不良反应包括甲状腺功能异常、抑郁或精神异常、心脏毒性及间质性肺炎等。结论:在抗病毒及免疫调节治疗的过程中干扰素的不良反应发生率高,用药前有必要对患者进行相关的用药教育,督促患者定期返院进行各种相关检查,以便及时监测并发现严重的药物不良反应,根据病情调整剂量或停用。临床医师及药师应熟知干扰素可能引起的各种不良反应。

OBJECTIVE To investigate common adverse drug reactions（ ADRs） as well as rare ADRs associated with interferon-α during antiviral treatment against chronic viral hepatitis. METHODS ADRs associated with interferon-α therapy against chronic viral hepatitis were collected and retrospectively investigated from our hospital in recent 3 years. RESULTS A total of 620 cases of ADR occurred in 176 patients,fever（ 56. 8%）,muscular soreness（ 36. 4%）,leucopenia（ 81. 8%） and flu-like symptoms（44. 3%） were common. Rare ADRs included thyroid dysfunction,depression or mental abnormality,heart toxicity,interstitial pneumonia,etc. CONCLUSION Incidences of ADRs associated with interferon-α were high during anti-viral and immunological treatment. It was necessary to have informed education for patients before interferon-α medication,supervise and urge them to return regularly for specific examinations to discover severe ADR in time,and adjust drug dose or suspend drug administration according to patients＇ conditions. Clinical physicians and pharmacists should know well all sorts of ADRs associated with interferon-α.