抗生素联合中药保留灌肠在子宫内膜炎患者辅助生殖中的应用价值

Clinical Application of Antibiotics Combined Chinese Herbal Retention Enema for Patients with Endometritis

目的探讨静脉滴注抗生素联合中药保留灌肠对试管婴儿助孕失败合并子宫内膜炎患者的治疗作用。方法将86例IVF周期中1次新鲜胚胎移植失败患者,分为两组。其中,对照组30例,宫腔镜提示正常宫腔;试验组56例,宫腔镜提示子宫内膜炎。对照组不予治疗,直接行冷冻胚胎移植。试验组分为单纯抗生素治疗组(A组)25例,抗生素联合中药保留灌肠组(B组)31例,试验两组给予治疗后行冷冻胚胎移植,比较各组临床妊娠率及胚胎种植率。结果给予冷冻胚胎移植后试验B组的临床妊娠率及胚胎种植率均高于对照组及试验A组,差异有统计学意义(P<0.0 5)。结论抗生素联合中药保留灌肠治疗子宫内膜炎可提高助孕失败后冷冻胚胎移植的临床妊娠率及胚胎种植率。

Objective To study the clinical effect of antibiotics combined Chinese herbal retention enema for patients with endometritis who failed in fresh embryo transfer treatment. Methods We collected 86 patients who were failed in fresh embryo transfer treatment. They were divided into two groups. Among them,30 patients without endometritis were collected as the control group,56 patients with endometritis were collected as the test group. Patients in the control group were performed the frozen embryo transfer directly without treatment. The test group was divided into A group and B group. Among the two test groups,A test group including 25 patients were treated by antibiotics only,while B test group including 31 patients were treated by antibiotics combined Chinese herbal retention enema before the frozen embryo transfer treatment. The clinical pregnancy rate and the embryo implantation rate were compared. Results Compared to the control group and A test group,the clinical pregnancy rate and the embryo implantation rate were higher in the B test group,there was statistical difference（ P〈0. 0 5）. Conclusion In frozen embryo transfer period,the clinical pregnancy rate and the embryo implantation rate can be improved in patients with endometritis who were treated by antibiotics combined Chinese herbal retention enema after the failed fresh embryo transfer period.