中西医结合干细胞移植治疗糖尿病足的临床研究进展

Clinical Progress of Treatment of Diabetic Foot by Stem Cell Transplantation Integrative Traditional Chinese and Western Medicine

糖尿病足属中医学"消渴病"继发的"血痹""脱疽""筋疽"等范畴,是指因糖尿病血管病变和(或)神经病变及感染等综合因素,导致慢性进行性波及肢体大、中、微血管,引起足部疼痛、皮肤深溃疡、肢体坏疽等病变,是糖尿病的严重并发症之一,临床治疗非常棘手,难以取得令人满意的疗效,最终导致截肢甚至危及生命。因此,临床上迫切需要找到创伤小、易接受、疗效好的方法。糖尿病足的治疗是个系统工程,单一的方法难以治愈,干细胞具有高度增殖和分化成为体内各种细胞的潜能,其可塑性强,为糖尿病足的治疗带来新前景,目前是国内外学者研究的热点之一。近年来中西医结合干细胞移植治疗法逐渐应用于本病中,其疗效明显优于单纯中医、单纯西医或单纯干细胞移植治疗。文章就中西医结合干细胞移植治疗糖尿病足的临床研究进展进行概括。

Objective The diabetic foot（ DF） belongs to the ＂ blood arthralgia＂, ＂ sphacelus ＂, ＂ tendon gangrene＂ and other disease of traditional Chinese medicine category,is secondary to diabetes. It is caused by diabetic vascular disease and（ or） neuropathy and infections as well as other factors,resulting in chronic progressive affected limb,micro vessel,causing foot pain,skin ulcers or gangrene of limbs in deep. It is one of the serious complications of diabetes,occasionally causing amputation and even death. It is hard to obtain satisfactory effect,and clinical treatment is very difficult. Therefore,there is an urgent need to find a new treatment with fewer traumas,easier delivery,and good curative effect. Treatment of DF is a system engineering,and single method is difficult to cure. Stem cells are capable of proliferation and differentiation into various kinds of cells. Their stronger plasticity brings new prospect for the treatment of DF. Currently,the stem cells attract attention of researchers worldwide. Traditional Chinese medicine and Western medicine combined with stem cell transplantation therapy has been gradually applied to the disease in recent years,its efficacy is better than pure Chinese medicine,western medicine or simple stem cell transplantation therapy.Here we review the clinical progress on stem cell transplantation integrative traditional Chinese and Western medicine therapy for the treatment of DF.