鸡骨香提取物抗炎镇痛作用的实验研究

Anti- inflammatory and anti-nociceptive effects of Croton crassifolius extract

目的:研究鸡骨香提取物的抗炎镇痛作用。方法:采用二甲苯实验、毛细血管通透性实验、角叉菜胶致大鼠足肿胀实验观察抗炎作用;采用醋酸扭体实验、热板实验观察镇痛作用。结果:鸡骨香醇提物、水提物能抑制二甲苯致小鼠耳肿胀、醋酸致小鼠毛细血管通透性增加、角叉菜胶致大鼠足肿胀,醇提物作用显著优于水提物;醇提物能明显延长醋酸致小鼠扭体反应潜伏期,醇提物、水提物能减少醋酸致小鼠扭体次数、对小鼠热板实验痛阈值无显著影响。结论:鸡骨香醇提物和水提物均有抗炎、抗外周性疼痛作用,醇提物的抗炎镇痛作用优于水提物。

Objective To observe the anti- inflammatory and anti- nociceptive effects of Croton crassifolius extract. Methods Anti- inflammatory effects were assessed by three models： xylene- induced ear swelling in mice,acetic acid- induced capillary permeability accentuation in mice and carrageenan- induced edema of the hind paw in rats. Anti- nociception was evaluated in mice using a hot- plate test and an acetic acid- induced writhing test. Results Compared with the model group,C. crassifolius showed the inhibitory effect on xylene- induced ear swelling in mice,suppressed acetic acid- induced capillary permeability accentuation in mice and carrageenan- induced paw edema. C. crassifolius showed no significant anti- nociceptive activity in the hot- plate test,however,it significantly reduced acetic acid- induced writhing,the ethanol extract also prolonged writhing latency. Conclusion C. crassifolius demonstrates significant anti- inflammatory and peripheral anti- nociceptive effects,the effects of ethanol extract were better than that of water extract.