乌司他丁辅助治疗15例高血压脑出血临床观察

Clinical observation of ulinastatin for adjuvant treatment of hypertensive cerebral hemorrhage

目的:探讨乌司他丁对高血压脑出血患者NSE浓度和hs-CRP的影响及脑保护作用。方法:选取30例高血压脑出血患者为研究对象,随机将其分为对照组与观察组各15例。对照组患者围术期给予常规治疗;观察组患者在对照组基础上应用乌司他丁治疗,比较两组患者手术前后NIHSS(神经功能缺损评分)、hs-CRP(超敏C反应蛋白)、不同时间点(入室时、麻醉诱导后、术后12h、24h、72h)颅内压、NSE浓度(神经元特异性烯醇化酶)及GCS(格拉斯哥)评分等情况。结果:观察组术后一周hs-CRP水平、NIHSS评分明显低于对照组,观察组术后12h、24h、72h NSE浓度明显低于对照组,观察组术后72h时GCS评分明显高于对照组,两组比较差异均有统计学意义(P<0.05)。结论:围术期应用乌司他丁能显著降低高血压脑出血患者hs-CRP、NSE水平,有利于神经保护、脑损伤减轻。

Objective To investigate the effects of ulinastatin on concentrations of NSE and hs- CRP on patients with hypertensive cerebral hemorrhage and brain protection. Methods Select 30 cases of hypertensive cerebral hemorrhage patients as the research object,were randomly divided into two groups,control group was received routine treatment group patients in the perioperative period,patients in observation group application of ulinastatin treatment based on control group,compared NIHSS（ score of nerve functional impairment）,hs- CRP（ high sensitivity C reactive protein）,different points（ anesthesia,after anesthesia induction,surgery after12 h,24h,72h）,intracranial pressure,NSE（ the concentration of neuron specific enolase）,GCS（ Glasgow） scores etc before and after operation between two groups. Results Observation of hs- CRP level,NIHSS score after one week group were significantly lower than the control group,12 h,24h,72 h of NSE concentration in observation group were significantly lower than those of the control group,72 h GCS score of patients in observation group was significantly higher than that in the control group,difference was statistically significant（ P〈0. 05）. Conclusion Perioperative application of ulinastatin can significantly reduce hs- CRP and NSE in patients with hypertensive intracerebral hemorrhage level,is conducive to the protection of nerves,relieve brain injury.