沉默信息调节因子2相关酶1在直肠癌中的表达及临床意义

Expression and Clinical Significance of Sir2-related Enzymes-1 in Colorectal Cancer

目的探讨沉默信息调节因子2相关酶1(SIRT1)在直肠癌中的表达及其临床意义。方法采用免疫组化法检测86例直肠癌组织和30例癌旁正常直肠组织中SIRT1的表达情况,并与临床病理资料进行相关性分析。结果直肠癌组织中SIRT1的阳性表达率为88.4%,癌旁正常组织阳性率为16.6%,显著高于癌旁正常直肠组织(P<0.001);直肠癌组织中SIRT1的表达与TNM分期(P<0.05)、淋巴结转移的有无(P<0.05)、肿瘤浸润深度(P<0.05)呈正相关;与肿瘤组织分化程度(P<0.05)呈负相关;而与性别、年龄、肿瘤直径无关(P>0.05)。结论 SIRT1在直肠癌中表达明显高于癌旁正常直肠组织,且与TNM分期、淋巴结转移、浸润深度及肿瘤分化程度密切相关。提示SIRT1在直肠癌发生发展过程中可能具有重要作用,可以作为直肠癌判断预后的重要指标之一。

Objective To investigate the expression and clinical significance of Sir2-related enzymes- 1 （SIRT1） in colorectal cancer. Methods The expression of SIRT1 was evaluated by immunohistochemistry in 86 selected cases of primary Colorectal cancer and 30 samples of normal rectum tissues besided carcinoma. The relationship of the expression and clinical pathological features were analyzed. Results The positive expression rate of SIRT1 in Colorectal cancer tissue was 88.4%, and significantly higher than in normal rectum tissue besided carcinoma （P 〈 0.001 ）. There were no correlation between the expression of SIRT1 and sex, age and tumor diameter, and significant positive correlation between the expression of SIRT1 and TNM stage （P 〈 0.05 ）, lymph node metastasis （P 〈 0.05 ）, infiltrating depth （P 〈 0.05 ）, and negagtive correlation between the expression of SIRT1 and tumor differentiation （P 〈 0.05 ）. Conclusion The positive expression rate of SIRT1 in colorectal cancer tissue was significantly higher than in normal rectum tissue besided carcinoma and intimate correlation with tumor differentiation, TNM stage, lymph node metastasis and Inf＇fitmt- ing depth. Conclusion SIRT1 may be an important assistance gene to diagnose and judge prognosis, and may improve diagnostic rate and auxiliari- ly judge prognosis as a important Colorectal cancer marker.