十二味化症汤加减配合米非司酮治疗子宫腺肌症30例观察

目的:探讨十二味化症汤配合米非司酮治疗子宫腺肌症的临床价值。方法:60例随机分为对照组和治疗组各30例。月经来潮后5天对照组口服米非司酮12.5mg,每日1次。治疗组使用米非司酮10.0mg,每日1次,同时联合十二味化症汤,口服每日两次、灌肠每晚1次,疗程3周。结果:治疗组雌二醇、促卵泡生成素和促黄体生成素水平均显著低于对照组(P<0.05)。治疗组发生关节酸痛、体重增加和痤疮的比率均显著低于对照组(P<0.05)。结论:十二味化症汤配合米非司酮治疗子宫腺肌症,能减少长期大量使用米非司酮后的不良反应。

Objective ： To explore twelve kinds of disease decoction combined with mifepristone in the treatment of the clinical value of uterine adenomyosis. Methods ： 60 patients, were randomly divided into two groups, each 30 cases, control group in the patients after 5 days of menstrual cramps by oral mifepristone 12.Smg / time, 1 times a day, treatment group at the same time point using mifepristone 10.0mg / time, l times a day, combined with twelve kinds of disease soup, oral two times a day, enema daily late 1 times, in 3 weeks after treatment in patients with E2 compared with estradiol, follicle stimulating hormone, luteinizing hormone FSH LH results, statistics and complications. Results： after the treatment, E2 estradiol, follicle stimulating hormone, luteinizing hormone FSH treatment after LH treatment group, estradiol, follicle stimulating hormone and luteinizing hormone levels were significantly lower than those in the control group （ P〈0.05 ） . Ratio of treatment group had joint pain, weight gain and acne were significantly lower than those in the control group （ P〈0.05 ） , the two groups occurrence rate differences in gastrointestinal discomfort with no statistical significance （ P〉0.05 ） . Conclusion： the twelve kinds of disease decoction combined with mifepristone in the treatment of adenomyosis of uterus, and can effectively reduce the adverse reaction of long-term use of mifepristone.