摘要
目的:优选九味益胃合剂的水回流提取工艺条件。方法:以君药丹参中水溶性成分丹酚酸B含量、赤芍中芍药苷含量和干膏得率的综合评分为考察指标,以浸泡时间、提取时间、加水量、提取次数等4个因素设计L9(34)正交试验优选九味益胃合剂提取工艺条件,并进行验证试验。结果:最优工艺为加8倍药材量水浸泡1 h,提取2次,每次提取1 h。3批样品验证试验综合评分分别为98.793、99.078、99.220(RSD<2%,n=3)。结论:九味益胃合剂优选工艺稳定可行。
OBJECTIVE:To optimize water reflux extraction technology of Jiuwei yiwei mixture.METHODS:With the overall score of the content of salvianoli acid B,a water-soluble component of the principal drug Salvia miltiorrhiza,the content of paeoniflorin in Paeonia Radix Rubra and dry ointment yield rate as the observed index,and taking soaking time,extraction time,amount of water added,and extraction times as the factors,L9(34)orthogonal test was designed to optimize the extraction technology of Jiuwei yiwei mixture.And the verification test was conducted.RESULTS:The optimal technology was to add water with an amount 8 times as much as that of the drugs to soak them for 1 h and to conduct extraction twice,1 h for each.The overall scores of 3 batches of samples in the verification test were respectively 98.793,99.078 and 99.220(RSD2%,n=3).CONCLUSIONS:The optimal technology for Jiuwei yiwei mixture is stable and feasible.
出处
《中国药房》
CAS
北大核心
2015年第19期2711-2713,共3页
China Pharmacy
关键词
九味益胃合剂
提取工艺
正交试验
丹酚酸B
芍药苷
干膏得率
Jiuwei yiwei mixture
Extraction technology
Orthogonal design
Salvianoli acid B
Paeoniflorin
Dry ointment yield rate