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儿童恙虫病致继发性噬血细胞综合征一例并文献复习 被引量：1

Scrub Typhus- associated Hemophagocytic Syndrome in Children: A Case Report and Literatures Review
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摘要 恙虫病致继发性噬血细胞综合征(HPS)在儿童中少见,病情凶险,易漏诊、误诊。本文报道了1例儿童恙虫病致HPS患儿,并复习相关文献,对该病误诊原因、临床表现、治疗策略进行总结,以指导临床早期诊断、有效治疗。 Scrub typhus - induced hemophagocytic syndrome in children is rare and severe. It is easy to be misdiagnosed and miss-diagnosed. This paper reported a case of scrub typhus-induced hemophagocytic syndrome in children, reviewed the published papers and attempted to provide references for its early diagnosis and effective treatment by analyzing the reasons for misdiagnosis,clinical manifestation and treatment strategy of this disease.
作者 周永海 夏芳琴 金江兵 留佩宁
机构地区 温州医科大学附属第二医院育英儿童医院儿童保健科
出处 《中国全科医学》 CAS CSCD 北大核心 2015年第17期2114-2116,共3页 Chinese General Practice
关键词 丛林斑疹伤寒 淋巴组织细胞增多症 嗜血细胞性 儿童 Scrub typhus Lymphohistiocytosis,hemophagocytic Child
分类号 R513.2 [医药卫生—内科学] R551.12 [医药卫生—血液循环系统疾病]
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参考文献9

  • 1Lin YH, Lin YH, Shi ZY. A case report of scrub typhus - associated hemophagocytic syndrome and a review of literature [ J ]. Jpn J Infect Dis, 2014, 67 (2): 115 - 117.
  • 2George MR. Hemophagocytic lymphohist- iocytosis : review of etiologies and management [ J]. J Blood Med, 2014 (5) : 69 -86.
  • 3王晓琳,王昭.获得性噬血细胞综合征研究进展[J].中华医学杂志,2010,90(14):1004-1006. 被引量：15
  • 4Henter J1, Home A, Arico M, el. al. HLH - 2004 : diagnosis and therapeutic guidelines for hemophagocytic lymphohistiocytosis [ J 1. Pcdiatr Blood Cancer, 2007, 48 (2) : 124 -131.
  • 5中国疾病预防控制中心.恙虫病预防控制技术指南(试行)[EB/OL].(2009-01-05)[2013-06-16].http://www.chinacdc.cn/tzgg/200901/t20090105_40316.htm.
  • 6Kwon HJ, Yoo IH, Lee JW, et al. Life - threatening scrub typhus with hemophagueytosis and acute respiratory distress syndrome in an infant [ J ]. J Trop Pediatr, 2013, 59 (1): 67-69.
  • 7Llayakrishnan MP, Veny .I, Fernze M. Rickettsial infection with hemophagocytosis [J]. Trop Doer,2011 ,41 (2) :111 - 112.
  • 8Han DK, Baek HJ, Shin MG, et al. Scrub typhus - associated severe hemophagocytic lymphnhistiocytosis with encephalomyelitis leading to permanent sequelae: a case report and review of the literature [ J]. J Pediatr Hematol Oncol, 2012, 34 (7): 531 -533.
  • 9Raiapakse S, Rodrigo C, Fernando SD. Drug treatment of scrub typhus [ J]. Trop Doct, 2011, 41 (1): 1-4.

二级参考文献17

  • 1Janka G.Familial and acquired hemophagocytic lymphohistiocytosis.Eur J Pediatr,2007,166:95-109.
  • 2Janka G.Hemophagocytic syndromes.Blood Rev,2007,21:245-253.
  • 3Fisman DN.Hemophagocytic syndromes and infection.Emerg Infect Dis,2000,6:601-608.
  • 4Lee SW,Wang CY,Lee BJ,et al.Hemophagocytic syndrome in Miliary tuberculosis presenting with noncaseating granulomas in bone marrow and liver.J Formos Med Assoc,2008,107:495-499.
  • 5Larroche C,Mouthon L.Pathogenesis of hemophagocytic syndrome (HPS).Autoimmunity Reviews,2004,3:69-75.
  • 6Filipovich AH.Hemophagocytic lymphohistiocytosis (HLH) and related disorders.Hematology Am Soc Hematol Educ Program,2009:127-131.
  • 7Okamoto M,Yamaguchi H,Isobe Y,et al.Analysis of triglyceride value in the diagnosis and treatment response of secondary hemophagocytic syndrome.Inter Med,2009,48:775-781.
  • 8Henter JI,Home AC,Egeler RM,et al.HLH-2004:Diagnostic and therapeutic guidelines for Hemophagocytic lymphohistiocytosis.Pediatr Blood Cancer,2007,48:124-131.
  • 9Allen CE,Yu X,Kozinetz CA,et al.Highly elevated ferritin levels and the diagnosis of hemophagocytic lymphohistiocytosis.Pediatr Blood Cancer,2008,50:1227-1235.
  • 10Wang Z,Wang Y,Wang J,et al.Early diagnostic value of low percentage of glycosylated ferritin in secondary hemophagocytic lymphohistiocytosis.Int J Hematol,2009,90:501 -505.

共引文献16

同被引文献4

引证文献1

中国全科医学
2015年 第17期

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