代谢酶基因多态致氯乙烯暴露人群染色体损伤易感性研究
Study on susceptibility of chromosomal damage in vinyl chloride exposed workers owing to genetic polymorphisms of metabolizing enzymes
摘要
通过双核淋巴细胞微核方法评价氯乙烯暴露人群染色体损伤水平,PCR法检测GSTT1、GSTM1基因缺失频率,PCR-RFLP检测CYP2E1 G/C、CYP2D6 G/C和GSTP1 G/A基因多态情况,Poisson回归分析代谢酶基因多态及其他危险因素对染色体损伤易感性的影响,发现性别、年龄、氯乙烯暴露、GSTP1和CYP2E1基因多态性可能与个体染色体损伤的发生风险有关,GSTP1 G/A和CYP2E1 G/C基因多态性可能是氯乙烯暴露人群染色体损伤的生物标志。
出处
《中国工业医学杂志》
CAS
2015年第3期182-184,共3页
Chinese Journal of Industrial Medicine
基金
国家自然科学基金资助项目(No.30671740)
参考文献9
-
1Neha S, Dheeraj G, Niti B, et al. Association of NAT2, GST and CYP2E1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity [J]. Tuberculosis, 2014, 94 (3): 293-298.
-
2Gu S Y, Zhang Z B, Wan X, et al. Genetic polymorphisms in CYP1A1, CYP2D6, UGT1A6, UGT1A7, and SULT1A1 genes and correlation with benzene exposure in a Chinese occupational population [J]. J Toxicol Environ Health A, 2007, 70 (11) : 916-924.
-
3Abbondandolo A, Bolognesi C, Barale R, et al. Age-ralated increase of baseline frequencies fo sister chromatid exchanges, chromosome aberrations, and micronuelei in human lymphocytes [ J]. Cancer Epi- demiol Biomarkers Prey, 1997, 6: 249-256.
-
4Ishikawa H. Evidence of association of the CYP2E1 genetic polymorphism with micronuclei frequency in human peripheral blood [J ]. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2004, 546 (1-2): 45-53.
-
5Micheline K V, Raluca A M, Franqoise M R, et al. The effects of GSTMI and GSTTI polymorphisms on micronucleus frequencies in hu- man lymphocytes in vivo [ J ]. Cancer Epidemiol Biomarkers Prey, 2006, 15 (5): 1038-1042.
-
6Hassan R D, Loulou K. Toxicogenetic profile and cancer risk in leba- nese [ J ]. Journal of Toxicology & Environmental Health: Part B, 2014, 17 (2): 95-125.
-
7Huang C Y, Huang K L, Cheng S J, et al. The GSTTI and CYP2E1 genotypes are possible factors causing vinyl chloride induced abnormal liver function [J]. Arch Toxicol, 1997, 71: 482-488.
-
8Schindler J, Li Y, Marion M J, et al. The effect of genetic polymor- phisms in the vinyl chloride metabolic pathway on mutagenic risk [ J]. J Hum Genet, 2007, 52 (5): 448-455.
-
9Xiang Z D, John N S, Martina K, et al. Mice lacking three loci enco- ding 14 glutathione transferase genes: A novel tool for assigning function to the GSTP, GSTM, and GSTT families [ J]. Drug Metabo- lism and Disposition, 2014, 42 (6) : 1074-1083.
-
1谭红汕,王琪,王爱红,冯楠楠,叶云杰,冯晓青,郑玉新,夏昭林.1，3-丁二烯致染色体损伤的遗传易感性与CYP2E1和GSTs基因多态性关系[J].环境与职业医学,2010,27(5):266-269. 被引量：1
-
2朱守民,程蔚,都凤仁,王爱红,夏昭林.氯乙烯接触工人DNA损伤与代谢酶基因多态关系研究[J].卫生研究,2005,34(6):655-657. 被引量：3
-
3王圣贤,甘志娟,姜宪尘.2009—2014年衢州市居民恶性肿瘤发病趋势及其影响因素分析[J].浙江预防医学,2016,28(3):262-264. 被引量：9
-
4李代蓉,周清华,郭占林,袁天柱,朱文,王艳萍,陈晓禾.CYP2E1基因多态性与肺癌遗传易感性的关系[J].第三军医大学学报,2008,30(13):1231-1234. 被引量：10
-
5冷曙光,程娟,张林媛,潘祖飞,戴宇飞,牛勇,孙耀峰,李斌,何凤生,郑玉新.焦炉工XRCC1基因多态性与淋巴细胞染色体损伤易感性的关系[J].中华预防医学杂志,2005,39(3):159-163. 被引量：4
-
6谭红汕,王琪,王爱红.1,3-丁二烯致染色体损伤的遗传易感性与CYP2E1和GSTs基因多态性的关系[J].环境与职业医学,2010,27(4):246-246.
-
7冀芳,郑颖佳,王琪,王威,仇玉兰,吴芬,柴尚建,李俊,夏昭林.氯乙烯作业工人染色体损伤及其遗传易感性[J].中华劳动卫生职业病杂志,2011,29(8):583-588. 被引量：1
-
8李水,原福胜.大气中金属元素对人双核淋巴细胞微核的影响[J].中国城乡企业卫生,2004,19(3):34-35.
-
9曹春莉.IL-6174G/C基因多态性与胃肿瘤易感性多因素分析研究[J].现代预防医学,2014,41(20):3756-3758. 被引量：3
-
10程娟,刘强,施建,牛勇,王亚东,王雅文,吴智君.代谢酶基因多态性与三氯乙烯作业工人染色体损伤关系的研究[J].工业卫生与职业病,2013,39(1):31-35. 被引量：4
