呼出气一氧化氮检测在支气管哮喘和慢性阻塞性肺疾病诊断中的价值

Value of the Detection of Fractional Exhaled Nitric Oxide in the Diagnosis of Bronchial Asthma and Chronic Obstructive Pulmonary Disease

目的:探讨呼出气一氧化氮(fractional exhaled nitric oxide,FeNO)检测在支气管哮喘(哮喘)和慢性阻塞性肺疾病诊断中的价值。方法:选择慢性阻塞性肺疾病患者、哮喘患者各120例以及120名健康志愿者,均测定FeNO值。结果:慢性阻塞性肺疾病患者、哮喘患者、健康志愿者的FeNO测定值分别为(25.8±15.6)ppb、(64.1±51.8)ppb、(18.8±7.3)ppb,慢性阻塞性肺疾病患者和哮喘患者的FeNO值与健康志愿者比较差异均有统计学意义(P<0.05),慢性阻塞性肺疾病患者与哮喘患者比较差异有统计学意义(P<0.01)。3组研究对象的年龄、身高、体质量等一般资料比较差异均无统计学意义。FeNO测定值与年龄、身高、体质量、体质量指数、第1秒用力呼气容积(FEVI)、第1秒用力呼吸容积与用力肺活量之比(FEVI/FVC)均不存在直线相关性(P>0.05)。结论:慢性阻塞性肺疾病及哮喘患者FeNO值均高于健康志愿者,FeNO测定值与FEVI、FEVI/FVC等均不存在直线相关性,其原因可能是研究采用的样本量偏少。

Objective：To explore the value of fractional exhaled nitric oxide（FeNO）in the diagnosis of bronchial asthma and chronic obstructive pulmonary disease（COPD）.Methods：A hundred and twenty patients with COPD,120 patients with asthma and 120 healthy volunteers were enrolled in this study.FeNO value was compared among the three groups.Results：FeNO value in patients with COPD,patients with asthma,healthy volunteers were（25.8±15.6）ppb,（64.1±51.8）ppb,（18.8±7.3）ppb,respectively.There was significant differences between the patients with COPD or asthma and the healthy volunteers（P〈0.05）,and there was significant difference between the patients with COPD and the patients with asthma（P〈0.01）.There was no significant difference in age,height,weight,and other general information among the three groups.There was no linear correlation between FeNO value and age,height,weight,body mass index,forced expiratory volume in the first second（FEVI）and FEVI to forced vital capacity（FEVI/FVC）.Conclusions：The measured value of FeNO in patients with COPD and asthma are higher than that of healthy volunteers.There is no linear correlation between the measured value of FeNO and other values such as FEVI and FEVI/FVC,etc.The reason may be small sample size in this study.