河北省沧州市成人糖化血红蛋白与血脂水平的流行病学调查

Epidemiological Investigation on Glycosylated Hemoglobin and Serum Lipid Levels in Adults in Cangzhou city of Hebei Province

目的:对河北省沧州市成人糖化血红蛋白(glycosylated hemoglobin,HbAlc)、血糖、血脂水平进行流行病学调查,为该市心血管疾病等有关疾病的防治提供依据。方法:于2011年11月—2012年9月对河北省沧州市6287名20岁以上体检者测量身高、体质量、血压等,检测HbAlc、空腹血糖(FPG)和血脂水平,并行肝脏彩超、胸部X线摄片、心电图等检查。结果:HbAlc总异常率为16.7%,其中男性HbAlc异常率为18.8%,女性HbAlc异常率为14.0%,男性显著高于女性(P<0.01);血脂总异常率为43.0%,其中男性血脂异常率为54%,女性血脂异常率为27%,男性显著高于女性(P<0.01)。血脂异常以高三酰甘油(TG)、低高密度脂蛋白胆固醇(HDL-C)为主。结论:河北省沧州市成人HbAlc、血脂异常率均高于全国平均水平,且男性高于女性,HbAlc、血脂异常与脂肪肝、动脉硬化等相关。

Objective：To perform epidemiological investigation on glycosylated hemoglobin（HbAlc）,blood glucose and serum lipid levels in adults in Cangzhou city of Hebei province,so as to provide evidence for prevention of cardiac vascular diseases and other related diseases.Methods：Cross-sectional survey research was done from Nov.2011 to Sep.2012 to detect the levels of HbAlc,fasting plasma glucose（FPG）and serum lipid levels,as well as the liver color ultrasonography,chest X-ray,electrocardiogram,height,weight and blood pressure in 6287 persons over 20 years old,who undertook physical examination,in Cangzhou city of Hebei province.Results：Among all subjects,the incidence of abnormal HbAlc was 16.7%,of which male（18.8%）and was higher than female（14.0%）with significant difference（P〈0.01）.The incidence of dyslipidemia was 43.0%,of which male（54%）was higher than female（27%）with significant difference（P〈0.01）.The incidences of high TG and low HDL-C were highlighted in dyslipidemia.Conclusions：The incidences of abnormal HbAlc and dyslipidemia in adults in Cangzhou city of Hebei province are higher than average levels in China.And the male incidences are higher than female.Abnormal HbAlc and dyslipidemia are correlated with fatty liver and arteriosclerosis.The 40-50 age group is the key age group to the prevention and treatment of diabetes mellitus.