生长抑素联合前列腺素E对急性胰腺炎患者微循环的改善作用及临床疗效分析

The clinical efficacy and the effect of somatostatin combined with prostaglandin E on microcirculation in acute pancreatitis

[目的]探讨生长抑素联合前列腺素E对急性胰腺炎患者微循环的改善作用及临床疗效分析。[方法]将120例重症胰腺炎患者随机分为研究组和对照组,每组60例。对照组患者给予前列腺素E和常规治疗,研究组患者在此基础上加用生长抑素治疗。比较2组患者的临床治疗效果,血流指标和微循环状态相关指标。[结果]治疗前血流量、血容量及通过时间和毛细血管通透性局部血供指标在2组间差异无统计学意义(P>0.05)。2组治疗后上述胰腺血流指标均显著改善(P<0.01),但研究组对上述指标的改善作用均显著优于对照组(P<0.05和P<0.01)。治疗前流态积分、综合积分、管襻数和管襻畸形率甲襞微循环指标在2组间差异无统计学意义(P>0.05)。2组治疗后上述甲襞微循环指标均显著改善(P<0.01),但研究组对上述指标的改善作用均显著优于对照组(P<0.05和P<0.01)。研究组死亡率为3.3%,对照组死亡率为15.0%,研究组死亡率显著低于对照组(P<0.05),研究组临床治愈时间为(31.3±4.3)d显著低于对照组的(40.0±5.4)d(P<0.05)。[结论]生长抑素联合前列腺素E可以有效改善急性胰腺炎患者的微循环状态,并以此改善患者的临床治疗效果,具有临床应用价值。

[Objective] To explore the clinical efficacy and effect of somatostatin combined with prostaglandin E on mierocireulation of patients with acute pancreatitis. [-Methods] 120 acute pancreatitis cases were equally randomized into treatment group and control group. The control group was given prostaglandin E and routine treatment. The experimental group was treated by somatostatin combined with prostaglandin E. The clinical curative effect, blood flow and microcirculation were compared between the two groups. [Results]Before treatment, blood flow, blood volume, transition time and capillary permeability were observed insignificant difference between the two groups（P〉0.05）. After treatment,the above indexes were significantly improved in treatment group than in the control group（P〈0.05 and P（0.01）. Be- fore treatment,score of the micro-blood-flow state and comprehensive score, number of capillary loop and vascular malformation rate had no significant difference between the two groups（P〉0.05）. After treatment,the above indexes were significantly improved in experimental group than in the control group（P〈0. 05 and P（0.01）. The mortality rate in treatment group was 3.3% ,significantly lower than the 15.0% in control group（P〈0.05）. The clinical cure time was 31.3±4.3 d in treatment group,which was significantly lower than that of 40.0 ± 5.4 d in control group（P〈0.05）. [Conclusion]somatostatin combined with prostaglandin E can improve the microcirculation of patients with acute pancreatitis.