岗梅根中酚类化学成分研究

Study on the phenolic constituents from the roots of Ilex Asprella

目的研究岗梅根的酚类化学成分。方法采用大孔树脂柱层析、反相硅胶生柱层析和凝胶柱层析等方法分离纯化岗梅根的化学成分,并根据波谱数据鉴定化合物的结构。结果从岗梅根的乙醇提取物中分离得到6个化合物,分别鉴定为咖啡酸（Ⅰ）、咖啡酸甲酯（Ⅱ）、绿原酸（Ⅲ）、隐绿原酸（Ⅳ）、3,5-O-二咖啡酰奎宁酸甲酯（Ⅴ）、丁香醛（Ⅵ）。结论化合物Ⅱ~Ⅵ为首次从该植物中分离得到。

Objective To investigate the phenolic constituents from Ilex Asprella. Methods The chemical constituents were isolated by macroporous resin,reverse phase silica gel and Sephadex LH-20 column chromatography. Their structures were elucidated with spectral analysis. Results Six compounds were isolated and identified as caffeic acid（ Ⅰ）,methyl caffeate（ Ⅱ）,chlorogenic acid（ Ⅲ）,cyclohexanecarboxylic acid（ Ⅳ）,3,5-dicaffeoylquinic acid methyl ester（ Ⅴ）,syringaldehyde（ Ⅵ）.Conclusion Compound Ⅱ-Ⅵ were isolated from this plant for the first time.