摘要
干扰素是一种具有广泛抗病毒、抗肿瘤和免疫调节作用的可溶性蛋白,是目前治疗病毒性肝炎、肝癌的疗效药,被广泛应用于临床。但因其在肝脏中富集较少,肾脏清除率很高,导致药物有效浓度较低从而影响治疗效果。本文对肝靶向干扰素的研究进展进行综述。
Interferon,a kind of soluble protein,displays a variety of bioactivities such as anti-virus,anti-tumor and immunomodulation,which is known as an effective medicine in viral hepatitis and liver cancer. However,owing to the less enriched in liver,the therapeutic effect of interferon is not ideal. This paper will review recent liver-targeting interferon development.
出处
《广东药学院学报》
CAS
2015年第3期416-419,共4页
Academic Journal of Guangdong College of Pharmacy
基金
国家科技部新药创制重大专项项目(2013ZX09103003-003)
关键词
病毒性肝炎
肝癌
干扰素
靶向药物
hepatitis
hepatic carcinoma
interferon
targeted drug
