不同剂量辛伐他汀治疗急性心肌梗死的效果观察及护理

Effect observation and nursing of different doses of simvastatin in the treatment of acute myocardial infarction

目的观察不同剂量辛伐他汀治疗急性心肌梗死的疗效,探讨护理对策。方法以本院收治的86例急性心肌梗死患者为研究对象,将其随机分成2组,在常规治疗基础上使用辛伐他汀,A组(43例)辛伐他汀用量20 mg,B组(43例)辛伐他汀用量40 mg,2组治疗过程中均给予综合护理干预,比较2组的治疗效果。结果 A组治疗后总有效率81.4%,B组治疗后总有效率95.4%,组间比较差异显著(P<0.05);2组治疗前TC、TG、LDL-C和CRP无显著性差异(P>0.05),治疗后B组各项指标明显优于A组(P<0.05);A组心血管事件发生率25.6%,B组心血管事件发生率9.3%,B组明显少于A组(P<0.05);A组不良反应率11.6%,B组不良反应率16.3%,组间比较无显著差异(P>0.05)。结论较高剂量剂量辛伐他汀辅助治疗急性心梗的疗效更佳,降低心血管不良事件,值得进步应用。

Objective To observe the effect of different doses of simvastatin in the treat- ment of acute myocardial infarction, and to explore the nursing countermeasures. Methods A total of 86 patients with acute myocardial infarction in our hospital were as the research objects, and were randomly divided into 2 groups, and all the patients used simvastatin on the basis of conventional treatment. A group with 43 cases was given simvastatin dosage for 20 mg, B group with 43 cases was given simvastatin dosage for 40 mg. Both 2 groups during the treatment were given comprehen- sive nursing intervention. The treatment effect of 2 groups was compared. Results After treat- ment, the total efficiency in A group was 95.4 % and 81.4 % in B group, the difference in the total efficiency between 2 groups was significant （P 〈 0.05）. Before treatment, there was no significant difference in TC, TG, LDL-C and CRP （P 〉 0.05） and the index of group B after the treatment was better that that in the A group （ P 〈 0. 0 5 ） . The incidence rate of cardiovascular events was 25.6 % in A group and 9.3 % in B group, and the incidence rate of cardiovascular events in B group was significantly less than that that in A group （P 〈 0.05）. Adverse reaction rate was 11.6 % in A group and 16.3 % in B group, there was no significant difference between 2 groups （P 〉0.05）. Conclusion The curative effect of higher dose simvastatin in adjuvant treatment of acute myocar- dial infarction is better and it can reduce cardiovascular adverse events, so it is worthy of application.