达泊西汀药物制备技术研究进展

Research Progress in Preparation Technique of Dapoxetine

达泊西汀是一种主要用于治疗男性早泄的选择性5-羟色胺再摄取抑制剂(SSRI)。目前该药合成有多种方法,本文主要概述了合成达泊西汀的化学不对称法和手性源法,重点介绍了化学不对称法制备达泊西汀的研究现状。

Dapoxetine is a potent selective serotonin re-uptake inhibitor（SSRI） used in the treatment of patients with premature ejaculation. Many methods are currently available for the synthesis of Dapoxetine.This paper reviewed the synthetic process of Dapoxetine by asymmetric synthesis or chiral pool synthesis, and summarized the status and progress of Dapoxetine preparation with the chemical methods.